Observational studyArthritis research & therapy2016
Continuous evolution of clinical phenotype in 578 Japanese patients with Behçet's disease: a retrospective observational study.
Observational study in Arthritis research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Behçet's Disease: A Comprehensive Review on the Role ofInternational journal of molecular sciences · 2023Pooled it
- Distinct clinical features between acute and chronic progressive parenchymal neuro-Behçet disease: meta-analysis.Scientific reports · 2017Pooled it
- Unmasking Behçet's disease in the European population: a case series report.Rheumatology international · 2026Article
- A case of intestinal Behçet disease in a deceased donor kidney transplantation recipient.Clinical transplantation and research · 2026Article
- Risk of intestinal involvement in mucocutaneous-onset Behçet's disease: data from the AIDA network registry.Frontiers in immunology · 2026Article
- Enhancing the Diagnosis of Behçet's Disease Using Machine Learning: A Comparative Study on Clinical Data From Saudi Arabia.International journal of telemedicine and applications · 2026Article
- Innovative polymer-based therapeutics targeting inflammation for responsive drug delivery in disease treatment.Inflammopharmacology · 2025Review
- Oral, not gut microbiota diversity, reflects the inflammation and neoplasia in patients with uveitis and vitreoretinal lymphoma.Journal of ophthalmic inflammation and infection · 2025Article
- Demographics and clinical manifestations in patients with Behçet's disease: a retrospective observational study from a non-endemic country.Rheumatology international · 2025Observational
- HLA-B5 prevalence in patients with spondyloarthritis and impact on disease phenotype: a multicentric case-control study.Rheumatology (Oxford, England) · 2025Observational
- Relation of Social Participation Restrictions with Worsening Quality of Life in Japanese Patients with Behçet's Disease: The 36-item Short Form Survey.JMA journal · 2025Article
- Gender disparities in Behçet's syndrome: identifying distinct phenotypes through cluster analysis.Immunologic research · 2024Article
- Association between uveitis onset and economic development in mainland China.BMC public health · 2023Article
- Measuring the Whole Wall Thickness of the Common Femoral Vein as a Distinctive Diagnostic Tool to Distinguish Behçet's Disease Presenting with Oral Ulcers from Recurrent Aphthous Stomatitis.Diagnostics (Basel, Switzerland) · 2023Article
- Challenges in the Timely Diagnosis of Behcet's Disease.Life (Basel, Switzerland) · 2023Review
- Update on the Diagnosis of Behçet's Disease.Diagnostics (Basel, Switzerland) · 2022Review
- Global epidemiology of vasculitis.Nature reviews. Rheumatology · 2022Review
- The association of Behçet's syndrome with HLA-B51 as understood in 2021.Current opinion in rheumatology · 2022Review
- Behçet uveitis: Current practice and future perspectives.Frontiers in medicine · 2022Review
- Epidemiologic and Etiological Features of Korean Patients With Behçet's Disease.Journal of rheumatic diseases · 2021Review
Corrections and comments
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Authors and funding
21 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been suggested that the phenotypes of Behçet's disease (BD) in Japan are changing. To ask whether the evolution of BD holds true in recent-onset cases in Japan, we performed a retrospective study.
methodsWe reviewed the records of 578 patients with BD who met the 1987 revised diagnostic criteria of the Behçet's disease research committee of Japan. The patients were divided into three groups based on the date of disease onset. We compared the demography, clinical features, and treatments among them with or without adjustment for the observation period. Patients having oral ulcers, genital ulcers, regional skin involvement, and uveitis are categorized as having complete-type BD, and the associated factors were determined by univariate and multivariate logistic regression analyses.
resultsMale patients had a higher propensity for uveitis and central nervous system (CNS) involvement, whereas female patients had higher rates of genital ulcers and arthritis. We found a significant trend in reduction of complete-type, genital ulcer, HLA-B51 carriers, and increment of gastrointestinal BD over time. Multiple regression analysis identified HLA-B51 positivity, earlier date of disease onset, and younger age of onset as independently associated with complete-type BD. Although treatments had been also chronologically changed, the causative relationship between therapeutic agents and phenotypical changes was not determined from the study.
conclusionThe present study revealed that phenotypical evolution was characterized by decreased incidence of the complete type and increment of gastrointestinal involvement in Japanese patients with BD during the last 30 years.
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