Evidence map›Paper›PMID 27716395›Full record

ArticleArthritis research & therapy2016

Thymosin β

Silvia Bosello, Giusy Peluso, Federica Iavarone, Barbara Tolusso, Irene Messana, Gavino Faa, Massimo Castagnola, Gianfranco Ferraccioli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Salivary Proteome Role in Infection and Immunity.Advances in experimental medicine and biology · 2026
    Review
  3. Thymosin βCells · 2024
    Review
  4. The Involvement of Alarmins in the Pathogenesis of Sjögren's Syndrome.International journal of molecular sciences · 2022
    Review
  5. Salivary biomarkers and proteomics: future diagnostic and clinical utilities.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Silvia BoselloDivision of Rheumatology, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
Giusy PelusoDivision of Rheumatology, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
Federica IavaroneInstitute of Chemistry and Clinical Biochemistry, Catholic University, Rome, Italy.
Barbara TolussoDivision of Rheumatology, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
Irene MessanaDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Gavino FaaDepartment of Surgery, Section of Pathology, University of Cagliari, Cagliari, Italy.
Massimo CastagnolaInstitute of Chemistry and Clinical Biochemistry, Catholic University, Rome, Italy.
Gianfranco FerraccioliDivision of Rheumatology, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy. gianfranco.ferraccioli@unicatt.it.
Agostino Gemelli University Polyclinic · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the present study, we investigated whether thymosin β (Tβ) in saliva and in minor salivary glands is differentially expressed in patients with primary Sjögren's syndrome (pSS) and patients with autoimmune diseases (systemic sclerosis [SSc], systemic lupus erythematosus [SLE], and rheumatoid arthritis [RA], with and without sicca syndrome [ss]).

methodsSaliva specimens of nine patients with pSS, seven with ss/SSc, seven with ss/SLE, seven with ss/RA, seven with SSc, seven with SLE, and seven with RA, as well as ten healthy subjects, were analyzed using a high-performance liquid chromatograph coupled with a mass spectrometer equipped with an electrospray ionization source to investigate the presence and levels of Tβ

resultsTβ

conclusionsOur data show that higher salivary Tβ expression characterizes patients with pSS, while Tβ

Indexed as

AgedAutoimmune DiseasesChromatography, High Pressure LiquidFemaleHumansImmunohistochemistryMiddle AgedProteomicsSalivaSalivary Glands, MinorSjogren's SyndromeSpectrometry, Mass, Electrospray IonizationThymosinThymosin beta(4)Thymosinthymosin beta(10)Thymosin beta(4)ImmunohistochemistryMinor salivary glandsProteomicsSalivaSjögren’s syndromeThymosin β10Thymosin β4

Identifiers

PMID27716395
PMCPMC5053072
OpenAlexW2528203266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.