ArticleBMC medicine2016
Back to the basics of ovarian aging: a population-based study on longitudinal anti-Müllerian hormone decline.
Article in BMC medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review.Human reproduction update · 2023Pooled it
- Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women.Human reproduction (Oxford, England) · 2022Pooled it
- Ovarian reserve and endothelial health in healthy reproductive-age women.The Journal of clinical endocrinology and metabolism · 2026Article
- A Functional SNP in the AMH Gene Is Associated with Litter Size in Dazu Black Goats.Animals : an open access journal from MDPI · 2026Article
- Low anti-Mullerian hormone in reproductive age is associated with MASLD in midlife.Hepatology communications · 2026Article
- Cortisol-to-cortisone ratio postpartum is associated with anti-Müllerian hormone a decade later: evidence from a prospective study.Endocrine connections · 2026Article
- From static snapshots to longitudinal trajectories: artificial intelligence in women's reproductive and ovarian health.Frontiers in endocrinology · 2026Review
- TransrectalFrontiers in medicine · 2026Article
- Reproductive prognosis factors in women with infertility and polycystic ovary syndrome undergoing in vitro fertilization techniques.JBRA assisted reproduction · 2025Article
- Efficacy of endovenous embolization for pelvic congestion syndrome and its impact on ovarian reserve.Reproductive biology and endocrinology : RB&E · 2025Article
- Association between anti-Mullerian hormone levels and age in women with endometriosis: insights from a population-based study.BMJ open · 2025Article
- Article
- AMH decline during chemotherapy reflects breast cancer cell DNA damage response (DDR) proficiency: the ONCO AMH1 pilot study.Journal of assisted reproduction and genetics · 2025Article
- Age and serum anti-Müllerian hormone levels as predictors of time to return of menses after chemotherapy.Reproduction & fertility · 2025Article
- The effect of environmental stressors on anti-mullerian hormone levels in Lebanese women: a retrospective study.PloS one · 2025Article
- The functional ovarian anatomy of 492 women aged 18-22 years: a population-based study in Norway.Human reproduction open · 2025Article
- PCOS Influences the Expression of AMHRII in the Endometrium of AEH During the Reproductive Age.Diagnostics (Basel, Switzerland) · 2024Article
- Dissecting the shared genetic architecture between anti-Müllerian hormone and age at menopause based on genome-wide association study.American journal of obstetrics and gynecology · 2024Article
- Anti-Müllerian hormone type II receptor protein expression in non-small cell lung cancer and the effect of AMH/AMHR2 signaling on cancer cell proliferation.Thoracic cancer · 2024Article
- Anti-Müllerian Hormone Level Determinants among Non-Polycystic-Ovary-Syndrome Women Undergoing In Vitro Fertilization: A Retrospective Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2024Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnti-Müllerian hormone (AMH) is currently used as an ovarian reserve marker for individualized fertility counseling, but very little is known of individual AMH decline in women. This study assessed whether the decline trajectory of AMH is uniform for all women, and whether baseline age-specific AMH levels remain consistently high or low during this trajectory.
methodsA total of 3326 female participants from the population-based Doetinchem Cohort Study were followed with five visits over a 20-year period. Baseline age was 40 ± 10 years with a range of 20-59 years. AMH was measured in 12,929 stored plasma samples using the picoAMH assay (AnshLabs). Decline trajectories of AMH were studied with both chronological age and reproductive age, i.e., time to menopause. Multivariable linear mixed effects models characterized the individual AMH decline trajectories.
resultsThe overall rate of AMH decline accelerated after 40 years of age. Mixed models with varying age-specific AMH levels and decline rates provided the significantly best fit to the data, indicating that the fall in AMH levels over time does not follow a fixed pattern for individual women. AMH levels remained consistent along individual trajectories of age, with an intraclass correlation coefficient (ICC) of 0.87. The ICC of 0.32 for AMH trajectories with time to menopause expressed the large variation in AMH levels at a given time before the menopause. The differences between low and high age-specific AMH levels remained distinguishable, but became increasingly smaller with increasing chronological and reproductive age.
conclusionsThis is the first study to characterize individual AMH decline over a long time period and broad age range. The varying AMH decline rates do not support the premise of a uniform AMH decline trajectory. Although age-specific AMH levels remain consistently high or low with increasing age, the converging trajectories and variance of AMH levels at a given time before menopause shed doubt on the added value of AMH to represent individualized reproductive age.
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