ArticleBMC urology2016
The relationship between depression and overactive bladder/urinary incontinence symptoms in the clinical OAB population.
Article in BMC urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adverse Childhood Experiences in Urogynecologic Patients
The APPROVE Trial: A Randomized Controlled Trial Evaluating the Efficacy and Safety of a Prescription Digital Therapeutic for Treatment of Overactive Bladder in Women
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acupuncture for treating overactive bladder in adults.The Cochrane database of systematic reviews · 2022Pooled it
- Beyond the bladder: incontinence-specific, physical, and psychological contributors to sexual function in women with urinary incontinence.The journal of sexual medicine · 2026Trial
- Interpretation of the Meaningfulness of Symptom Reduction with Vibegron in Patients with Overactive Bladder: Analyses from EMPOWUR.Advances in therapy · 2022Trial
- Overactive Bladder and Suicidal Ideation: A National Cross-Sectional Study Identifying Depression as the Primary Mediator.Neurourology and urodynamics · 2026Article
- Overactive bladder phenotype induced by chronic activation of hypothalamic neuroendocrine stress pathways in rats with no extrinsic behavioral stress applied.Scientific reports · 2025Article
- Does Anticholinergic Burden Influence Therapeutic Success in Patients with Treatment-naïve Overactive Bladder?European urology open science · 2025Article
- Depression mediates the association between lipid accumulation products and overactive bladder.Scientific reports · 2025Article
- Mediating role of SII in the association between LC9 and overactive bladder.Scientific reports · 2025Article
- Body Mass Index and Depressive Symptoms as Risk Factors for Urinary Incontinence in Women: A Nationally Representative Study.International urogynecology journal · 2025Article
- Association between novel inflammatory markers and overactive bladder: a cross-sectional study of NHANES 2009 to 2018.BMC urology · 2025Article
- The Association between Depression and Overactive Bladder: A Cross-Sectional Study of NHANES 2011-2018.International urogynecology journal · 2025Article
- The GPR39 Receptor Plays an Important Role in the Pathogenesis of Overactive Bladder and Corticosterone-Induced Depression.International journal of molecular sciences · 2024Article
- Steps toward identification of a novel cue-positive overactive bladder phenotype in women with high-bother urinary urgency.American journal of clinical and experimental urology · 2024Article
- Intake of dietary flavonoids in relation to overactive bladder among U.S. adults: a nutritional strategy for improving urinary health.Frontiers in nutrition · 2024Article
- Neurogenic Lower Urinary Tract Symptoms, Fatigue, and Depression-Are There Correlations in Persons with Multiple Sclerosis?Biomedicines · 2023Article
- The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis.International neurourology journal · 2023Article
- Stress-induced symptom exacerbation: Stress increases voiding frequency, somatic sensitivity, and urinary bladder NGF and BDNF expression in mice with subthreshold cyclophosphamide (CYP).Frontiers in urology · 2023Article
- Daily symptom associations for urinary urgency and anxiety, depression and stress in women with overactive bladder.International urogynecology journal · 2022Article
- Compensatory bladder behaviors ("coping") in women with overactive bladder.Neurourology and urodynamics · 2022Article
- Clustering of patients with overactive bladder syndrome.BMC urology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundTo investigate the relationship between depression and overactive bladder (OAB)/urinary incontinence symptoms among the clinical OAB population.
methodsPatients who were diagnosed with overactive bladder (OAB) and age-matched control subjects without OAB were enrolled. Depression symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS-D). OAB/incontinence symptoms were assessed using the validated questionnaires: ICIQ-UI, ICIQ-OAB, UDI-6, IIQ-7, and OAB-q.
results27.5 % of OAB patients in our study had depression (HADS ≥8), and 12 % of OAB patients had moderate to severe depression (HADS-D ≥11). OAB patients reported significantly higher HADS-D depression scores compared to age-matched controls (5.3 ± 3.9 versus 2.8 ± 3.9, p = 0.004). OAB patients with depression reported more severe incontinence symptoms (ICIQ-UI), greater bother and more impact on quality of life (UDI-6, IIQ-7) compared to OAB patients without depression (p = 0.001, 0.01, <0.001, respectively). However there were no differences in ICIQ-OAB and OAB-q. Among OAB patients, there were positive correlations between the severity of depression symptoms and OAB/incontinence symptoms (p-values <0.001 to 0.035).
conclusions27.5 % of OAB patients have depression. OAB patients with depression reported more severe urinary incontinence symptoms, greater bother and more impact on quality of life compared to those without depression. Future studies are needed to further examine the mechanistic links between depression and OAB/urinary incontinence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.