Evidence map›Paper›PMID 27716229›Full record

Trial reportBMC anesthesiology2016

Particulate-steroid betamethasone added to ropivacaine in interscalene brachial plexus block for arthroscopic rotator cuff repair improves postoperative analgesia.

Kunitaro Watanabe, Joho Tokumine, Tomoko Yorozu, Kumi Moriyama, Hideaki Sakamoto, Tetsuo Inoue

3 registry-linked trialsOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04073069 phase4completednot on this mapstarted 2019, after this paper: background citation

Pre-emptive Scalp Infiltration With Diprospan Plus Ropivacaine for Postoperative Pain After Craniotomy in Adults

TypeinterventionalSponsorBeijing Tiantan HospitalRan2019 to 2021Enrolled96ConditionsPain, Postoperative, Post-Craniotomy HeadacheArmsThe DR group, The R group
NCT04153396 phase4completednot on this mapstarted 2021, after this paper: background citation

Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy (PRE-EASE)

TypeinterventionalSponsorBeijing Tiantan HospitalRan2021 to 2022Enrolled116ConditionsPain, Postoperative, NeurosurgeryArmsThe Treatment group, The Control group
NCT05175001 phase4unknown statusnot on this mapstarted 2021, after this paper: background citation

Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Thoracic Paravertebral Nerve Block for Chronic Post-thoracotomy Pain

TypeinterventionalSponsorAffiliated Hospital of Nantong UniversityRan2021 to 2023Enrolled100ConditionsChronic PainArmsDiprospan, Ropivacaine
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Review
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  12. A Historical Analysis of Randomized Controlled Trials in Rotator Cuff Tears.International journal of environmental research and public health · 2020
    Review
  13. Article
  14. Article
  15. Article
  16. [Peripheral nerve block and rebound pain: literature review].Brazilian journal of anesthesiology (Elsevier)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kunitaro WatanabeDepartment of Anesthesiology, Kyorin University School of Medicine, 6-20-2 Sinkawa, Mitaka, Tokyo, 181-8611, Japan.
Joho TokumineDepartment of Anesthesiology, Kyorin University School of Medicine, 6-20-2 Sinkawa, Mitaka, Tokyo, 181-8611, Japan. ii36469@wa2.so-net.ne.jp.
Tomoko YorozuDepartment of Anesthesiology, Kyorin University School of Medicine, 6-20-2 Sinkawa, Mitaka, Tokyo, 181-8611, Japan.
Kumi MoriyamaDepartment of Anesthesiology, Kyorin University School of Medicine, 6-20-2 Sinkawa, Mitaka, Tokyo, 181-8611, Japan.
Hideaki SakamotoDepartment of Anesthesia, Hino Municipal Hospital, 4-3-1, Tamadaira, Hino, Tokyo, 191-0062, Japan.
Tetsuo InoueDepartment of Anesthesia, Hino Municipal Hospital, 4-3-1, Tamadaira, Hino, Tokyo, 191-0062, Japan.
Kyorin University · JPNagano Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDexamethasone added to local anesthetic for brachial plexus block improves postoperative pain after arthroscopic rotator cuff repair, as compared with the use of local anesthetic alone. Dexamethasone is present in non-particulate form in local anesthetic solution, while betamethasone is partially present in particulate form. The particulate betamethasone gradually decays and is expected to cause its longer-lasting effect. This study investigated the postoperative analgesic effect of betamethasone added to ropivacaine for brachial plexus block in patients who underwent arthroscopic rotator cuff repair.

methodsThis was a prospective, randomized, triple-blind study of 44 patients undergoing arthroscopic rotator cuff repair surgery. Ultrasound-guided interscalene brachial plexus block, involving 20 mL of 0.375 % ropivacaine (group R) or 19 mL of 0.375 % ropivacaine with 4 mg (1 mL) of betamethasone (group BR), was administered and surgery was performed under general anesthesia. After surgery, the pain score was recorded at 12 h after surgery, and on the first, second, and seventh postoperative day. Analgesia duration, offset time of motor block, frequency of rescue analgesic administration, postoperative nausea/vomiting, and sleep disturbance during the night after surgery were recorded. The numerical values were expressed as median [interquartile range]. P values < 0.05 were considered statistically significant.

resultsThe duration of analgesia was significantly prolonged in group BR (group BR: 19.1 h [16.6, 20.9 h], group R: 13.3 h [11.6, 16.5 h], p < 0.001). The pain scores at 12 h after surgery and on the first and seventh day after surgery were significantly lower in group BR than in group R. The duration of motor block was significantly prolonged in group BR. The frequency of rescue analgesic administration and the sleep disturbance rate were significantly lower in group BR. There was no difference in postoperative nausea/vomiting between the two groups.

conclusionsBetamethasone added to local anesthetic in interscalene brachial plexus block improved postoperative pain after arthroscopic rotator cuff repair, and betamethasone prolonged the duration of analgesia by almost 6 h.

trial registrationUniversity Hospital Medical Information Network Center Clinical Trials Registration System ( UMIN000012899 ).

Indexed as

AgedAmidesAnalgesicsAnesthesia, GeneralAnesthetics, LocalArthroscopyBetamethasoneBrachial Plexus BlockDouble-Blind MethodFemaleGlucocorticoidsHumansMaleMiddle AgedPostoperative PainProspective StudiesAmidesAnalgesicsAnesthetics, LocalBetamethasoneGlucocorticoidsRopivacaineArthroscopic rotator cuff repairBetamethasoneInterscalene brachial plexus blockPostoperative pain

Identifiers

PMID27716229
PMCPMC5050572
OpenAlexW2527945455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.