ArticleBMC medical genomics2016
The Anatomy to Genomics (ATG) Start Genetics medical school initiative: incorporating exome sequencing data from cadavers used for Anatomy instruction into the first year curriculum.
Article in BMC medical genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- DNA sequencing of anatomy lab cadavers to provide hands-on precision medicine introduction to medical students.BMC medical education · 2020Article
- Genomics Education in the Era of Personal Genomics: Academic, Professional, and Public Considerations.International journal of molecular sciences · 2020Review
- First Responder to Genomic Information: A Guide for Primary Care Providers.Molecular diagnosis & therapy · 2019Review
- Physician preparedness for big genomic data: a review of genomic medicine education initiatives in the United States.Human molecular genetics · 2018Review
- A Rare Case of Human Diphallia Associated with Hypospadias.Case reports in urology · 2018Article
- Extraction of amplifiable DNA from embalmed human cadaver tissue.BMC research notes · 2017Article
- Application of active learning modalities to achieve medical genetics competencies and their learning outcome assessments.Advances in medical education and practice · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increasing use of next generation DNA sequencing in clinical medicine is exposing the need for more genetics education in physician training. We piloted an initiative to determine the feasibility of incorporating exome sequencing data generated from DNA obtained from cadavers used for teaching Anatomy into a first year medical student integrated block-style course.
methodsWe optimized the procedure to obtain DNA for exome sequencing by comparing the quality and quantity of DNA isolated from several tissues by two different extraction methods. DNA was sequenced using exome capture and analyzed using standard methods. Single nucleotide variants (SNVs), as well as small insertions/deletions, with potential functional impact were selected by faculty for student teams to independently investigate and prepare presentations on their findings.
resultsA total of seven cadaver DNAs were sequenced yielding high quality results. SNVs were identified that were associated, with known physical traits and disease susceptibility, as well as pharmacogenomic phenotypes. Students presented findings based on correlation with known clinical information about the cadavers' diseases and traits.
conclusionExome sequencing of cadaver DNA is a useful tool to integrate Anatomy with Genetics and Biochemistry into a first year medical student core curriculum.
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