Evidence map›Paper›PMID 27716211›Full record

Trial reportCardiovascular diabetology2016

A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics.

Katherine E Beaney, Claire E Ward, Dauda A S Bappa, Nadine McGale, Anna K Davies, Shashivadan P Hirani, KaWah Li, Philip Howard, Dwaine R Vance, Martin A Crockard and 3 more

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01891786 (A Randomised Control Trial), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01891786 nacompletednot on this map

A Randomised Control Trial (RCT) to Investigate the Effectiveness of a Selfmanagement Intervention and Personalised Genetic Risk Information to Reduce Risk of Coronary Heart Disease in Patients With Type 2 Diabetes.

TypeinterventionalSponsorCity, University of LondonRan2013 to 2016Enrolled211ConditionsCoronary Heart Disease, Type 2 DiabetesArmsSelf-Management Intervention, Risk Result
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Review
  3. Genomic medicine for the 21Annals of the Royal College of Surgeons of England · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Katherine E BeaneyBritish Heart Foundation Laboratories, Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, University Street, London, UK.
Claire E WardMolecular Diagnostics Group, Randox Laboratories Ltd, Crumlin, UK.
Dauda A S BappaBritish Heart Foundation Laboratories, Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, University Street, London, UK.
Nadine McGaleSchool of Health Sciences, City University London, Northampton Square, London, UK.
Anna K DaviesSchool of Health Sciences, City University London, Northampton Square, London, UK.
Shashivadan P HiraniSchool of Health Sciences, City University London, Northampton Square, London, UK.
KaWah LiBritish Heart Foundation Laboratories, Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, University Street, London, UK.
Philip HowardBritish Heart Foundation Laboratories, Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, University Street, London, UK.
Dwaine R VanceMolecular Diagnostics Group, Randox Laboratories Ltd, Crumlin, UK.
Martin A CrockardMolecular Diagnostics Group, Randox Laboratories Ltd, Crumlin, UK.
John V LamontMolecular Diagnostics Group, Randox Laboratories Ltd, Crumlin, UK.
Stanton NewmanSchool of Health Sciences, City University London, Northampton Square, London, UK.
Steve E HumphriesBritish Heart Foundation Laboratories, Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, University Street, London, UK. steve.humphries@ucl.ac.uk.
City, University of London · GBRandox (United Kingdom) · GBBritish Heart Foundation · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits.

methodsTen-year coronary heart disease (CHD) risk was calculated using the UKPDS score. Genetic CHD risk was determined by genotyping 19 single nucleotide polymorphisms (SNPs) using Randox's Cardiac Risk Prediction Array and calculating a gene score (GS). Accuracy of the array was assessed by genotyping a subset of pre-genotyped samples (n = 185).

resultsOverall, 10-year CHD risk ranged from 2-72 % but did not differ between the randomisation groups (p = 0.13). The array results were 99.8 % concordant with the pre-determined genotypes. The GS did not differ between the Caucasian participants in the CoRDia SMI plus risk group (n = 66) (p = 0.80) and a sample of UK healthy men (n = 1360). The GS was also associated with LDL-cholesterol (p = 0.05) and family history (p = 0.03) in a sample of UK healthy men (n = 1360).

conclusionsCHD risk is high in this group of T2D subjects. The risk array is an accurate genotyping assay, and is suitable for estimating an individual's genetic CHD risk. Trial registration This study has been registered at ClinicalTrials.gov; registration identifier NCT01891786.

Indexed as

Polymorphism, Single NucleotideAdultAgedCase-Control StudiesCoronary Artery DiseaseDiabetes Mellitus, Type 2Diabetic AngiopathiesFemaleGene Expression ProfilingGenetic Association StudiesGenetic MarkersGenetic Predisposition to DiseaseHumansMaleMiddle AgedOligonucleotide Array Sequence AnalysisGenetic MarkersCoronary heart diseaseGene scoreRisk predictionType 2 diabetesUKPDS score

Identifiers

PMID27716211
PMCPMC5048451
OpenAlexW2527866168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.