Evidence map›Paper›PMID 27716209›Full record

Trial reportBMC medicine2016

Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial.

Mark Ng Tang Fui, Luke A Prendergast, Philippe Dupuis, Manjri Raval, Boyd J Strauss, Jeffrey D Zajac, Mathis Grossmann

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01616732 (Effect of Testosterone and Diet on Weight), which is not on this map. Cited by 52 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 5 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01616732 phase2completednot on this map

Effect of Testosterone and Diet on Weight

TypeinterventionalSponsorAustin HealthRan2013 to 2015Enrolled100ConditionsObesity in MenArmsTestosterone, placebo
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 5 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Effect of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Male Sexual Function: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Pooled it
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  15. Sex-differential testosterone response to long-term weight loss.International journal of obesity (2005) · 2024
    Observational
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  17. Review
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mark Ng Tang FuiDepartment of Medicine Austin Health, University of Melbourne, 145 Studley Road, Heidelberg, VIC, 3084, Australia.
Luke A PrendergastDepartment of Medicine Austin Health, University of Melbourne, 145 Studley Road, Heidelberg, VIC, 3084, Australia.
Philippe DupuisDepartment of Medicine Austin Health, University of Melbourne, 145 Studley Road, Heidelberg, VIC, 3084, Australia.
Manjri RavalDepartment of Endocrinology, Austin Health, 300 Waterdale Road, Heidelberg West, VIC, 3081, Australia.
Boyd J StraussDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton Road, Clayton, VIC, 3800, Australia.
Jeffrey D ZajacDepartment of Medicine Austin Health, University of Melbourne, 145 Studley Road, Heidelberg, VIC, 3084, Australia.
Mathis GrossmannDepartment of Medicine Austin Health, University of Melbourne, 145 Studley Road, Heidelberg, VIC, 3084, Australia. mathisg@unimelb.edu.au.
University of Melbourne · AUAustin Health · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. We hypothesised that testosterone treatment augments diet-induced loss of fat mass and prevents loss of muscle mass.

methodsWe conducted a randomised double-blind, parallel, placebo controlled trial at a tertiary referral centre. A total of 100 obese men (body mass index ≥ 30 kg/m

resultsA total of 82 men completed the study. At study end, compared to controls, cases had greater reductions in fat mass, with a mean adjusted between-group difference (MAD) of -2.9 kg (-5.7 to -0.2; P = 0.04), and in visceral fat (MAD -2678 mm

conclusionsWhile dieting men receiving placebo lost both fat and lean mass, the weight loss with testosterone treatment was almost exclusively due to loss of body fat.

trial registrationclinicaltrials.gov, identifier NCT01616732 , registration date: June 8, 2012.

Indexed as

Absorptiometry, PhotonAdipose TissueBody CompositionBody WeightCombined Modality TherapyDiet, ReducingDouble-Blind MethodHumansMaleMiddle AgedObesityTestosteroneTestosteronetestosterone undecanoateBody compositionCaloric restrictionObesityTestosterone

Identifiers

PMID27716209
PMCPMC5054608
OpenAlexW2527863576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.