Observational studyBMC infectious diseases2016
Carbapenem-Resistant Klebsiella pneumoniae influences the outcome of early infections in liver transplant recipients.
Observational study in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A comprehensive evaluation of risk factors for mortality, infection and colonization associated with CRGNB in adult solid organ transplant recipients: a systematic review and meta-analysis.Annals of medicine · 2024Pooled it
- Applicability of common inflammatory markers in diagnosing infections in early period after liver transplantation in intensive care setting.Scientific reports · 2020Trial
- Development and internal validation of a predictive nomogram for early postoperative bacterial infections following liver transplantation in patients with hepatocellular carcinoma.Journal of gastrointestinal oncology · 2026Article
- Clinical Outcomes of Bloodstream Infections in Liver Transplant Recipients: A Ten-Year Single-Center Retrospective Analysis, from Türkiye.Antibiotics (Basel, Switzerland) · 2026Article
- Clinical characteristics and outcomes of liver transplant recipients with carbapenem resistant klebsiella pneumonia infection.Frontiers in cellular and infection microbiology · 2026Article
- Effectiveness and safety of ceftazidime/avibactam versus polymyxin B in liver transplant recipients with carbapenem-resistant organism infections: a real-world cohort study.Journal of pharmaceutical policy and practice · 2026Article
- Impact of Perioperative Antibiotic Prophylaxis Targeting Multidrug-Resistant Gram-Negative Bacteria on Postoperative Infection Rates in Liver Transplant Recipients.Diagnostics (Basel, Switzerland) · 2025Article
- Epidemiology and Risk Prediction Model of Multidrug-Resistant Organism Infections After Liver Transplant Recipients: A Single-Center Cohort Study.Bioengineering (Basel, Switzerland) · 2025Article
- Carbapenem-resistantWorld journal of gastroenterology · 2025Article
- Article
- A retrospective observational study of the treatment with polymyxin B for liver transplantation recipients infected by multidrug-resistant gram-negative bacteria.Journal of clinical pharmacy and therapeutics · 2022Observational
- Effects of preservative fluid associated possible donor-derived carbapenem-resistant Klebsiella Pneumoniae infection on kidney transplantation recipients.BMC nephrology · 2022Article
- Ceftazidime-Avibactam for the Treatment of Multidrug-Resistant Pathogens: A Retrospective, Single Center Study.Antibiotics (Basel, Switzerland) · 2022Article
- Epidemic, risk factors of carbapenem-resistantFrontiers in cellular and infection microbiology · 2022Article
- Analysis of Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Infection and Its Effect on the Outcome of Early Infection After Kidney Transplantation.Frontiers in cellular and infection microbiology · 2021Article
- Ceftazidime-Avibactam as Salvage Treatment for Infections Due to Carbapenem-ResistantInfection and drug resistance · 2021Article
- Bacterial and Fungal Infections After Liver Transplantation: Microbial Epidemiology, Risk Factors for Infection and Death with Infection.Annals of transplantation · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfections remain a leading cause of morbidity and mortality among liver transplant (LT) recipients. The aim of our study was to define the factors associated with outcome of early bacterial and fungal infections in a cohort of patients who underwent LT at the University Hospital of Ancona over a nine year period.
methodsAll consecutive patients who underwent LT in our center were considered. An early infection was defined as occurring in the first month post-transplantation.
resultsAmong 330 patients who underwent LT from August 2005 to October 2014, 88 (27 %) had at least one infection documented within 30 days after transplantation. In 54 cases only one site was involved, in 34 cases ≥2 sites. There were 43 (30 %) pneumonia, 40 (27 %) surgical site infections, 31 (22 %) blood stream infections, and 30 (21 %) urinary tract infections. Gram-negative bacteria accounted for 64 % of the culture-positive cases, followed by Gram-positive bacteria (30 %) and fungi (6 %). A high proportion of drug-resistant strains was found within either Gram-negative (79 %) or Gram-positive (81 %) bacteria. There were 27 out 88 patients (31 %) who died within 180 days from the transplant. Factors independently associated with a higher risk of mortality were: renal replacement therapy (HR 11.797 [CI95 % 3.082-45.152], p < 0.0001), multisite infections (HR 4.865 [CI95 % 1.417-16.700], p = 0.012) and being infected with carbapenem-resistant Klebsiella pneumoniae (CRKP; HR 5.562 [CI95 % 1.186-26.088], p = 0.030).
conclusionsOverall, these data indicate that early infections in LT patients are characterized by significant mortality. In particular, an early infection caused by CRKP has an adverse impact on survival in these patients suggesting an urgent need for adopting preventive measures to avoiding this complication.
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