ArticleBMC gastroenterology2016
Cirrhosis related functionality characteristic of the fecal microbiota as revealed by a metaproteomic approach.
Article in BMC gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Isolation, Characterization, Genome Annotation, and Evaluation of Hyaluronidase Inhibitory Activity in Secondary Metabolites ofInternational journal of molecular sciences · 2024Article
- Advances in multi-omics integrated analysis methods based on the gut microbiome and their applications.Frontiers in microbiology · 2024Review
- Nonalcoholic Fatty Liver Disease and the Intestinal Microbiome: An Inseparable Link.Journal of clinical and translational hepatology · 2023Review
- Article
- Liver metabolomic characteristics in three different rat models of deficiency based on ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- [Research progress on the correlation between changes in gut microbiota and sarcopenia in patients with cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- Current therapeutic modalities and chemopreventive role of natural products in liver cancer: Progress and promise.World journal of hepatology · 2023Review
- Current Applications of Fecal Microbiota Transplantation in Functional Constipation.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Gut microbiota and immune system in liver cancer: Promising therapeutic implication from development to treatment.World journal of gastrointestinal oncology · 2021Review
- Gut microbiota signatures in Schistosoma japonicum infection-induced liver cirrhosis patients: a case-control study.Infectious diseases of poverty · 2021Article
- Autoimmune Hepatitis: Shifts in Gut Microbiota and Metabolic Pathways among Egyptian Patients.Microorganisms · 2020Article
- Disease severity and proton pump inhibitor use impact strongest on faecal microbiome composition in liver cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2020Article
- Gut Microbiota, Peroxisome Proliferator-Activated Receptors, and Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2020Review
- Review
- Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far?Diseases (Basel, Switzerland) · 2019Review
- Metaproteomics of the human gut microbiota: Challenges and contributions to other OMICS.Clinical mass spectrometry (Del Mar, Calif.) · 2019Review
- Functional Microbiomics in Liver Transplantation: Identifying Novel Targets for Improving Allograft Outcomes.Transplantation · 2019Review
- Combining amplicon sequencing and metabolomics in cirrhotic patients highlights distinctive microbiota features involved in bacterial translocation, systemic inflammation and hepatic encephalopathy.Scientific reports · 2018Article
- Abnormal Gut Microbiota Metabolism Specific for Liver Cirrhosis.Frontiers in microbiology · 2018Article
- Gut Microbiome-based Therapeutics in Liver Cirrhosis: Basic Consideration for the Next Step.Journal of clinical and translational hepatology · 2017Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntestinal microbiota operated as a whole and was closely related with human health. Previous studies had suggested close relationship between liver cirrhosis (LC) and gut microbiota.
methodsTo determine the functional characteristic of the intestinal microbiota specific for liver cirrhosis, the fecal metaproteome of three LC patients with Child-Turcotte-Pugh (CTP) score of A, B, and C, and their spouse were first compared using high-throughput approach based on denaturing polyacrylamide gel electrophoresis and liquid chromatography-tandem mass spectrometry in our study.
resultsA total of 5,020 proteins (88 % from bacteria, 12 % form human) were identified and annotated based on the GO and KEGG classification. Our results indicated that the LC patients possessed a core metaproteome including 119 proteins, among which 14 proteins were enhanced expressed and 7 proteins were unique for LC patients compared with the normal, which were dominant at the function of carbohydrate metabolism. In addition, LC patients have unique biosynthesis of branched chain amino acid (BCAA), pantothenate, and CoA, enhanced as CTP scores increased. Those three substances were all important in a wide array of key and essential biological roles of life.
conclusionsWe observed a highly comparable cirrhosis-specific metaproteome clustering of fecal microbiota and provided the first supportive evidence for the presence of a LC-related substantial functional core mainly involved in carbohydrate, BCAA, pantothenate, and CoA metabolism, suggesting the compensation of intestinal microbiota for the fragile and innutritious body of cirrhotic patients.
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