ArticleBMC microbiology2016
Longitudinal survey of Clostridium difficile presence and gut microbiota composition in a Belgian nursing home.
Article in BMC microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of Clostridioides difficile contamination in healthcare and non-healthcare environments: a global systematic review and meta-analysis.International health · 2026Pooled it
- Metagenomic analysis reveals distinct patterns of gut microbiota features with diversified functions inGut microbes · 2025Article
- Understanding crosstalk between the gut and liver microbiome: pathogenesis to therapeutic approaches in liver cancer.Cancer cell international · 2025Review
- Bacterial Contamination of the Surgical Site at the Time of Elective Caesarean Section in Belgian Blue Cows-Part 2: Identified by 16Sr DNA Amplicon Sequencing.Veterinary sciences · 2023Article
- External Ear Canal Evaluation in Dogs with Chronic Suppurative Otitis Externa: Comparison of Direct Cytology, Bacterial Culture and 16S Amplicon Profiling.Veterinary sciences · 2022Article
- Gut Microbiota Composition Associated withPathogens (Basel, Switzerland) · 2022Review
- First Descriptive Analysis of the Faecal Microbiota of Wild and Anthropized Barbary Macaques (Biology · 2022Article
- Article
- Relationship between Intestinal Microflora and Hepatocellular Cancer Based on Gut-Liver Axis Theory.Contrast media & molecular imaging · 2022Review
- An Osmotic Laxative Renders Mice Susceptible to Prolonged Clostridioides difficile Colonization and Hinders Clearance.mSphere · 2021Article
- Prevalence and Risk Factors for Multidrug-Resistant Organisms Colonization in Long-Term Care Facilities Around the World: A Review.Antibiotics (Basel, Switzerland) · 2021Review
- Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study.Metabolites · 2021Article
- Computational modeling of the gut microbiota reveals putative metabolic mechanisms of recurrent Clostridioides difficile infection.PLoS computational biology · 2021Article
- Gut Dysbiosis andFrontiers in microbiology · 2021Review
- Wild primate microbiomes prevent weight gain in germ-free mice.Animal microbiome · 2020Article
- Effect of increasing levels of rice distillers' by-product on growth performance, nutrient digestibility, blood profile and colonic microbiota of weaned piglets.Asian-Australasian journal of animal sciences · 2020Article
- Intestinal Microbiota in Elderly Inpatients withInfection and drug resistance · 2020Article
- Colonisation with pathogenic drug-resistant bacteria andAntimicrobial resistance and infection control · 2019Article
- Consortium of Probiotics Attenuates Colonization ofFrontiers in microbiology · 2019Article
- Preliminary feasibility for recruiting and retaining black and white females to provide fecal samples for longitudinal research.Gut pathogens · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreasing age, several co-morbidities, environmental contamination, antibiotic exposure and other intestinal perturbations appear to be the greatest risk factors for C. difficile infection (CDI). Therefore, elderly care home residents are considered particularly vulnerable to the infection. The main objective of this study was to evaluate and follow the prevalence of C. difficile in 23 elderly care home residents weekly during a 4-month period. A C. difficile microbiological detection scheme was performed along with an overall microbial biodiversity study of the faeces content by 16S rRNA gene analysis.
resultsSeven out of 23 (30.4 %) residents were (at least one week) positive for C. difficile. C. difficile was detected in 14 out of 30 diarrhoeal samples (43.7 %). The most common PCR-ribotype identified was 027. MLVA showed that there was a clonal dissemination of C. difficile strains within the nursing home residents. 16S-profiling analyses revealed that each resident has his own bacterial imprint, which was stable during the entire study. Significant changes were observed in C. difficile positive individuals in the relative abundance of a few bacterial populations, including Lachnospiraceae and Verrucomicrobiaceae. A decrease of Akkermansia in positive subjects to the bacterium was repeatedly found.
conclusionsA high C. difficile colonisation in nursing home residents was found, with a predominance of the hypervirulent PCR-ribotype 027. Positive C. difficile status is not associated with microbiota richness or biodiversity reduction in this study. The link between Akkermansia, gut inflammation and C. difficile colonisation merits further investigations.
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