ArticleBMC genetics2016
Genetic signals of high-altitude adaptation in amphibians: a comparative transcriptome analysis.
Article in BMC genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Responses of host energy status, intestinal structure and gut microbiota during post-hibernation recovery in high- and low-altitude populations of the plateau frogFrontiers in physiology · 2026Article
- Population Genomics Reveals Local Adaptation Related to Temperature Variation in Two Stream Frog Species: Implications for Vulnerability to Climate Warming.Molecular ecology · 2025Article
- Ecometabolomics reveal physiological adaptations of Asiatic toads (Bufo gargarizans Cantor, 1842) to different environments along an altitudinal gradient.Frontiers in zoology · 2025Article
- Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation in the Qinghai Toad-Headed LizardBiology · 2025Article
- Selection on the vascular-remodelingEvolution letters · 2025Article
- The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation.BMC genomics · 2024Review
- Article
- The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation.bioRxiv : the preprint server for biology · 2024Article
- Genomic Gigantism is not Associated with Reduced Selection Efficiency in Neotropical Salamanders.Journal of molecular evolution · 2024Article
- Context-dependent effects of thermal acclimation on physiological correlates of animal personality in Asiatic toads.Proceedings. Biological sciences · 2024Article
- Microbial diversity in mountain-dwelling amphibians: The combined effects of host and climatic factors.iScience · 2024Article
- Modified Metabolism and Response to UV Radiation: Gene Expression Variations Along an Elevational Gradient in the Asiatic Toad (Bufo gargarizans).Journal of molecular evolution · 2022Article
- Genomic signatures of thermal adaptation are associated with clinal shifts of life history in a broadly distributed frog.The Journal of animal ecology · 2022Article
- Article
- Thermal conditions predict intraspecific variation in senescence rate in frogs and toads.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Comparison of hematological traits and oxygenation properties of hemoglobins from highland and lowland Asiatic toad (Bufo gargarizans).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Review
- Article
- Molecular convergent and parallel evolution among four high-elevation anuran species from the Tibetan region.BMC genomics · 2020Article
- Multi-Tissue Transcriptomes Yield Information on High-Altitude Adaptation and Sex-Determination inGenes · 2019Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-altitude adaptation provides an excellent system for studying how organisms cope with multiple environmental stressors and interacting genetic modifications. To explore the genetic basis of high-altitude adaptation in poikilothermic animals, we acquired transcriptome sequences from a high-altitude population and a low-altitude population of the Asiatic toad (Bufo gargarizans). Transcriptome data from another high-altitude amphibian, Rana kukunoris and its low-altitude relative R. chensiensis, which are from a previous study, were also incorporated into our comparative analysis.
resultsMore than 40,000 transcripts were obtained from each transcriptome, and 5107 one-to-one orthologs were identified among the four taxa for comparative analysis. A total of 29 (Bufo) and 33 (Rana) putative positively selected genes were identified for the two high-altitude species, which were mainly concentrated in nutrient metabolism related functions. Using SNP-tagging and F
conclusionsAmphibians clearly employ different genetic mechanisms for high-altitude adaptation compared to endotherms. Modifications of genes associated with nutrient metabolism feature prominently while genes related to hypoxia tolerance appear to be insignificant. Poikilotherms represent the majority of animal diversity, and we hope that our results will provide useful directions for future studies of amphibians as well as other poikilotherms.
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