Evidence map›Paper›PMID 27715410›Full record

ArticleAutophagy2016

KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression.

R Santarelli, M Granato, G Pentassuglia, V Lacconi, M S Gilardini Montani, R Gonnella, M Tafani, M R Torrisi, A Faggioni, M Cirone

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

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  16. Knockout of Atg5 inhibits proliferation and promotes apoptosis of DF-1 cells.In vitro cellular & developmental biology. Animal · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

R Santarellia Department of Experimental Medicine , Sapienza University of Rome , Rome , Italy.
M Granatoa Department of Experimental Medicine , Sapienza University of Rome , Rome , Italy.
G Pentassugliaa Department of Experimental Medicine , Sapienza University of Rome , Rome , Italy.
V Lacconia Department of Experimental Medicine , Sapienza University of Rome , Rome , Italy.
M S Gilardini Montania Department of Experimental Medicine , Sapienza University of Rome , Rome , Italy.
R Gonnellaa Department of Experimental Medicine , Sapienza University of Rome , Rome , Italy.
M Tafania Department of Experimental Medicine , Sapienza University of Rome , Rome , Italy.
M R Torrisib Istituto Pasteur-Fondazione Cenci Bolognetti , Department of Clinical and Molecular Medicine , Sapienza University of Rome , Rome , Italy.
A Faggionia Department of Experimental Medicine , Sapienza University of Rome , Rome , Italy.
M Cironea Department of Experimental Medicine , Sapienza University of Rome , Rome , Italy.
Sapienza University of Rome · ITAzienda Ospedaliera Sant'Andrea · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously shown that Kaposi sarcoma-associated herpesvirus (KSHV) impairs monocyte differentiation into dendritic cells (DCs). Macroautophagy/autophagy has been reported to be essential in such a differentiating process. Here we extended these studies and found that the impairment of DC formation by KSHV occurs through autophagy inhibition. KSHV indeed reduces CAST (calpastatin) and consequently decreases ATG5 expression in both THP-1 monocytoid cells and primary monocytes. We unveiled a new mechanism put in place by KSHV to escape from immune control. The discovery of viral immune suppressive strategies that contribute to the onset and progression of viral-associated malignancies is of fundamental importance for finding new therapeutic approaches against them.

Indexed as

AutophagyCell DifferentiationAutophagy-Related Protein 5BiomarkersB-LymphocytesCalcium-Binding ProteinsCell LineHerpesviridae InfectionsHerpesvirus 8, HumanHumansHuman Umbilical Vein Endothelial CellsMitogen-Activated Protein Kinase 9MonocytesPhosphorylationTetradecanoylphorbol AcetateAutophagy-Related Protein 5BiomarkersCalcium-Binding ProteinscalpastatinMitogen-Activated Protein Kinase 9Tetradecanoylphorbol AcetateATG5autophagyCAPN/calpainCAST/calpastatindendritic cellsherpesvirusKSHVMAPK/JNKmonocytesSQSTM1/p62THP-1

Identifiers

PMID27715410
PMCPMC5173267
OpenAlexW2528258774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.