ArticleOcular immunology and inflammation2017
Cellular Infiltrate in Rheumatoid Arthritis-associated Paracentral Corneal Ulceration.
Article in Ocular immunology and inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Corneal ring infiltrate- far more than Acanthamoeba keratitis: review of pathophysiology, morphology, differential diagnosis and management.Journal of ophthalmic inflammation and infection · 2023Review
- Corneal ulcers with non-infectious appearance caused by nasolacrimal duct obstruction or canaliculitis.American journal of ophthalmology case reports · 2022Article
- Acute corneal melting one week after an uncomplicated cataract surgery in a patient who previously underwent eyelid radiation and with undiagnosed rheumatoid arthritis: a case report.Arquivos brasileiros de oftalmologiaArticle
- Acute postoperative paracentral corneal melting and perforation after uncomplicated cataract surgery in a patient with inadvertent rheumatoid arthritis.Arquivos brasileiros de oftalmologiaArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate an immunopathogenesis of central and paracentral corneal ulceration associated with rheumatoid arthritis.
methodsSparse infiltrating cells in the ulcer area were identified by immunohistochemistry applied to archived formalin fixed, paraffin embedded tissues that had been recovered from patients undergoing penetrating keratoplasty necessitated by rheumatoid-associated central or paracentral corneal ulceration.
resultsClinically, the ulcers presented as non-infiltrated lesions with a modicum of other ocular inflammation. Sparse T-lymphocytes were consistently identified in the subepithelial areas adjacent to the ulcer, with some neutrophils and macrophages in the stroma. B-lymphocytes were not detected. MHC Class II antigens reactivity was noted on some infiltrating cells and on corneal endothelium of two specimens.
conclusionsImmunohistochemistry of archival tissue facilitated detection and identification of sparse infiltrate in this infrequent corneal melting. Selective, consistent finding of T-lymphocyte infiltration in the ulcer area supports an immunopathogenesis of this clinical entity.
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