ArticlePhysical review letters2016
Nonadditive Compositional Curvature Energetics of Lipid Bilayers.
Article in Physical review letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Inside the membrane: a closer look using elastic scattering techniques and friends.European biophysics journal : EBJ · 2026Review
- The Role of Flexibility in the Bioactivity of Short α-Helical Antimicrobial Peptides.Antibiotics (Basel, Switzerland) · 2025Review
- How pore formation in complex biological membranes is governed by lipid composition, mechanics, and lateral sorting.PNAS nexus · 2025Article
- Lipid redistribution due to a cell-cell fusion pore.Biophysical journal · 2024Article
- Softening in Two-Component Lipid Mixtures by Spontaneous Curvature Variance.The journal of physical chemistry. B · 2024Article
- The Role of Lipid Intrinsic Curvature in the Droplet Interface Bilayer.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Softening in two-component lipid mixtures by spontaneous curvature variance.bioRxiv : the preprint server for biology · 2023Article
- Lipid redistribution in the highly curved footprint of Piezo1.Biophysical journal · 2023Article
- Determination of Elastic Parameters of Lipid Membranes with Molecular Dynamics: A Review of Approaches and Theoretical Aspects.Membranes · 2022Review
- Distribution of cholesterol in asymmetric membranes driven by composition and differential stress.Biophysical journal · 2022Article
- Molecular mechanisms of spontaneous curvature and softening in complex lipid bilayer mixtures.Biophysical journal · 2022Article
- Molecular Mechanisms Underlying Caveolin-1 Mediated Membrane Curvature.The Journal of membrane biology · 2022Review
- Molecular Shape Solution for Mesoscopic Remodeling of Cellular Membranes.Annual review of biophysics · 2022Review
- Determinants of Lipid Domain Size.International journal of molecular sciences · 2022Article
- Full scale structural, mechanical and dynamical properties of HIV-1 liposomes.PLoS computational biology · 2022Article
- Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis.Cell reports · 2021Article
- Asymmetric Lipid Membranes under Shear Flows: A Dissipative Particle Dynamics Study.Membranes · 2021Article
- Spatial extent of a single lipid's influence on bilayer mechanics.Physical review. E · 2021Article
- Structural and functional consequences of reversible lipid asymmetry in living membranes.Nature chemical biology · 2020Review
- Sphingomyelin Is Essential for the Structure and Function of the Double-Membrane Vesicles in Hepatitis C Virus RNA Replication Factories.Journal of virology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The unique properties of the individual lipids that compose biological membranes together determine the energetics of the surface. The energetics of the surface, in turn, govern the formation of membrane structures and membrane reshaping processes, and thus they will underlie cellular-scale models of viral fusion, vesicle-dependent transport, and lateral organization relevant to signaling. The spontaneous curvature, to the best of our knowledge, is always assumed to be additive. We describe observations from simulations of unexpected nonadditive compositional curvature energetics of two lipids essential to the plasma membrane: sphingomyelin and cholesterol. A model is developed that connects molecular interactions to curvature stress, and which explains the role of local composition. Cholesterol is shown to lower the number of effective Kuhn segments of saturated acyl chains, reducing lateral pressure below the neutral surface of bending and favoring positive curvature. The effect is not observed for unsaturated (flexible) acyl chains. Likewise, hydrogen bonding between sphingomyelin lipids leads to positive curvature, but only at sufficient concentration, below which the lipid prefers negative curvature.
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