ArticleJournal of clinical laboratory analysis2017
Comparing calculated free testosterone with total testosterone for screening and diagnosing late-onset hypogonadism in aged males: A cross-sectional study.
Article in Journal of clinical laboratory analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Expression profiles of circular RNAs in spermatozoa from aging men.Molecular biology reports · 2023Article
- Association between hypertriglyceridemic waist phenotype and hypogonadism in Taiwanese adult men.PloS one · 2022Article
- Impact of statin use on overall and time to biochemical failure following radical prostatectomy or radiation therapy.World journal of urology · 2021Article
- Change of preoperative symptoms of the late-onset hypogonadism syndrome after robot-assisted radical prostatectomy.Current urology · 2021Article
- Hypogonadism and its treatment among prostate cancer survivors.International journal of impotence research · 2021Review
- Prevalence of late-onset hypogonadism among middle-aged and elderly males in China: results from a national survey.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study is to compare calculated free testosterone (cFT) and total testosterone (T) in predicting late-onset hypogonadism (LOH) in middle-aged and elderly males.
methodsWe surveyed a random sample of 608 males between the ages of 45 and 87 years from Shanghai, China. The Aging Male Symptoms (AMS) questionnaire and the Androgen Deficiency in Aging Male (ADAM) questionnaire were completed by the subjects. Testosterone (T), sex hormone-binding globulin (SHBG), albumin, and other blood biochemical indexes were measured in 332 males. The corresponding cFT was obtained using the Vermeulen formula and the correlations between T and cFT were analyzed by SPSS statistical software.
resultsAmong the 332 males who underwent biochemical evaluation, 289 males (87.0%) was positively screened by the ADAM questionnaire and 232 males (69.9%) by the AMS questionnaire. As suggested by linear regression, cFT exhibited a negative correlation with age in both ADAM+ and AMS+ group, whereas T did not appear to have significant correlation with age. Besides, there were statistically significant differences in cFT (P<.001) in the AMS questionnaire.
conclusionsCalculated free testosterone levels are more reliable than T levels for diagnosing LOH in middle-aged and elderly males.
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Registered trials
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