ArticleJournal of veterinary internal medicine2016
Evaluation of Basal Serum or Plasma Cortisol Concentrations for the Diagnosis of Hypoadrenocorticism in Dogs.
Article in Journal of veterinary internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- Evaluation of basal cortisol and the adrenocorticotropic hormone stimulation test in 982 dogs undergoing investigation for hypoadrenocorticism.Journal of veterinary internal medicine · 2026Article
- Analytical and clinical agreement between the Siemens Immulite 2000 veterinary cortisol and standard cortisol assays in canine serum.Journal of veterinary internal medicine · 2026Article
- Predicting the likelihood of hypoadrenocorticism in dogs using signalment and routine laboratory results with an ensemble machine learning predictive model.Journal of veterinary internal medicine · 2026Article
- Pharmacokinetics and pharmacodynamics of desoxycorticosterone pivalate in dogs with hypoadrenocorticism.Journal of veterinary internal medicine · 2026Article
- Biological variation of baseline serum cortisol concentration in healthy dogs, part 2: clinical applications.Frontiers in veterinary science · 2026Article
- Associations between canine temperament and salivary concentrations of cortisol and serotonin.PloS one · 2026Article
- Biological variation of baseline serum cortisol concentration in healthy dogs, part 1: variance components.Frontiers in veterinary science · 2026Article
- Computed Tomography Volumetric Measurements of Adrenal Glands in 26 Dogs Under One Year of Age: A Retrospective Study.Veterinary sciences · 2025Article
- Coagulation Status Assessment in Dogs with Chronic Enteropathy Using Viscoelastic Point-of-Care Coagulation Monitor.Animals : an open access journal from MDPI · 2025Article
- Prospective Ultrasonographic Evaluation of Adrenal Glands in a Population of Beagle Puppies and Functional Analysis of Basal Cortisol Levels in Blood.Veterinary sciences · 2025Article
- Reassessing the role of basal cortisol in ACTH stimulation testing for canine hypoadrenocorticism: insights from a large UK referral and first-opinion dataset.Frontiers in veterinary science · 2025Article
- Comparison of prednisolone and alternative glucocorticoid dosing protocols for canine hypoadrenocorticism: insights from a survey-based study.Frontiers in veterinary science · 2025Article
- Comparison between typical primary and eunatraemic, eukalaemic hypoadrenocorticism: 92 cases.Irish veterinary journal · 2024Article
- Can we predict hypoadrenocorticism in dogs with resting hypocortisolemia? A predictive model based on clinical, haematological, and biochemical variables.Frontiers in veterinary science · 2024Article
- Effects of heat stress on oxidative balance and sperm quality in dogs.Frontiers in veterinary science · 2024Article
- Comparison of Cortisol Concentrations in Different Matrices in Alpine Ibex (Animals : an open access journal from MDPI · 2023Article
- Clinical utility of an immunoglobulin A-based serological panel for the diagnosis of chronic enteropathy in dogs.Journal of veterinary internal medicine · 2023Article
- Diagnosis of canine spontaneous hypoadrenocorticism.Canine medicine and genetics · 2022Review
- Urinary cortisol-creatinine ratio in dogs with hypoadrenocorticism.Journal of veterinary internal medicine · 2022Article
- Effect of heat stress on vital and hematobiochemical parameters of healthy dogs.Veterinary world · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies that included limited numbers of affected dogs have suggested basal cortisol concentrations ≤55 nmol/L (2 μg/dL) are sensitive, but nonspecific, for a diagnosis of hypoadrenocorticism. A detailed assessment of the diagnostic utility of basal cortisol concentrations is warranted. HYPOTHESIS/
objectivesTo evaluate the utility of basal cortisol concentrations for the diagnosis of hypoadrenocorticism in a large number of dogs, including those with and without serum electrolyte abnormalities. ANIMALS: Five hundred and twenty-two dogs, including 163 dogs with hypoadrenocorticism, 351 dogs with nonadrenal gland illness, and 8 dogs with equivocal results.
methodsRetrospective study. Basal and post-ACTH cortisol concentrations and sodium and potassium concentrations were collected from medical records. A receiver operating characteristic (ROC) curve was constructed for basal cortisol concentrations by standard methodologies. Sensitivity, specificity, and predictive values were determined for various cut-points.
resultsThe area under the ROC curve was 0.988 and was similarly excellent regardless of serum electrolyte concentrations. At the most discriminatory cut-point of 22 nmol/L (0.8 μg/dL), sensitivity and specificity were 96.9 and 95.7%, respectively. A basal cortisol concentration of ≤55 nmol/L (2 μg/dL) resulted in a sensitivity of 99.4%. Conversely, a basal cortisol concentration of ≤5.5 nmol/L (0.19 μg/dL) resulted in a specificity of 99.1%. CONCLUSIONS AND CLINICAL IMPORTANCE: Similar to findings in previous studies, basal cortisol concentrations >55 nmol/L (2 μg/dL) are useful in excluding a diagnosis of hypoadrenocorticism. Interestingly, excellent specificities and positive predictive values were observed at lower cut-point cortisol concentrations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.