ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016
Prognostic Value of Lymph Node Status and Extent of Lymphadenectomy in Pancreatic Neuroendocrine Tumors Confined To and Extending Beyond the Pancreas.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Impact of Regional Metastasis on Survival for Patients with Nonfunctional Pancreatic Neuroendocrine Tumors: A Systematic Review.Annals of surgical oncology · 2024Pooled it
- The Landmark Series: Surgical Management of Functioning and Non-Functioning Pancreatic Neuroendocrine Tumors.Annals of surgical oncology · 2025Review
- Novel Surgical Initiatives in Gastroenteropancreatic Neuroendocrine Tumours.Current oncology reports · 2025Review
- Accuracy and Prognostic Impact of Nodal Status on Preoperative Imaging for Management of Pancreatic Neuroendocrine Tumors: A Multi-Institutional Study.Annals of surgical oncology · 2024Article
- Surgical and Endoscopic Resection of Duodenal Neuroendocrine Tumors Have Similar Disease-Specific Survival Outcome.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Use of indocyanine green near-infrared lymphography to detect sentinel lymph nodes in a dog with a malignant insulinoma: a case report.Frontiers in veterinary science · 2023Article
- A novel tool to predict nodal metastasis in small pancreatic neuroendocrine tumors: A multicenter study.Surgery · 2022Article
- Reconsideration of operative indications in pancreatic neuroendocrine neoplasms.World journal of surgical oncology · 2022Article
- Preoperative prediction of lymph node metastasis in nonfunctioning pancreatic neuroendocrine tumors from clinical and MRI features: a multicenter study.Insights into imaging · 2022Article
- [Surgery of pancreatic neuroendocrine neoplasms: state of the art].Chirurgie (Heidelberg, Germany) · 2022Review
- Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms.World journal of clinical oncology · 2022Article
- Surgical Treatment of Patients with Poorly Differentiated Pancreatic Neuroendocrine Carcinoma: An NCDB Analysis.Annals of surgical oncology · 2022Article
- Enucleation Is a Feasible Procedure for Well-Differentiated pNEN-A Matched Pair Analysis.Cancers · 2022Article
- Neuroendocrine neoplasms of the gallbladder: early detection and surgery is key to improved outcome.Langenbeck's archives of surgery · 2022Article
- Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.World journal of gastroenterology · 2021Review
- Identifying Risk Factors and Patterns for Early Recurrence of Pancreatic Neuroendocrine Tumors: A Multi-Institutional Study.Cancers · 2021Article
- The Landmark Series: Pancreatic Neuroendocrine Tumors.Annals of surgical oncology · 2021Article
- c-Myc promotes lymphatic metastasis of pancreatic neuroendocrine tumor through VEGFC upregulation.Cancer science · 2021Article
- Diffusion-Weighted MRI Predicts Lymph Node Metastasis and Tumor Aggressiveness in Resectable Pancreatic Neuroendocrine Tumors.World journal of surgery · 2020Article
- The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors.Pancreas · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of lymph node (LN) status and lymphadenectomy (LA) on survival in pancreatic neuroendocrine tumors (pNETs) remains controversial. We evaluated the impact of tumor extension and grade on nodal metastasis and survival.
methodsSurgical pNET patients were queried in the Surveillance Epidemiology and End Results (SEER) database (1998-2012, N = 981). Factors associated with LN status were analyzed by logistic regression and by Cox analyses.
resultsFor T1-T2 tumors, N status was associated only with tumor size. N status (p = 0.001), grade (p < 0.001), age (p = 0.001), and sex (p = 0.007) predicted overall survival (OS). For T3-T4, grade (p < 0.001), sex (p = 0.004), size (p = 0.013), and age (p = 0.007) but not N status (p = 0.789) predicted OS. For T1-T2, disease-specific survival (DSS; p = 0.003) and OS (p = 0.008) were longer for N0 vs N1, while N0 vs NX had similar OS (p = 0.59) and DSS (p = 0.80). While a difference was seen in DSS for NX vs N1 (p = 0.04), no significant difference in OS was seen (p = 0.08). For T3-T4, N status did not affect DSS (p = 0.365) or OS (p = 0.454). For all T groups and any N status, extended LA (≥10 nodes resected) was not associated with OS.
conclusionWhile in T1-T2 pNET N1 status is a predictor of negative OS, similar outcome between NX and N0 supports limited LN resection in selected patients. Extended LA is unlikely to be helpful in T3-T4.
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