ReviewCurrent osteoporosis reports2016
Finite Element-Based Mechanical Assessment of Bone Quality on the Basis of In Vivo Images.
Review in Current osteoporosis reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Bone-Targeted Therapies and Spinal Morphometry in Postmenopausal Osteoporosis: A Real-World Longitudinal Retrospective Study.Bioengineering (Basel, Switzerland) · 2026Article
- Quantification of plant structure-function relationships through micro-CT imaging-based finite element modeling.The Plant journal : for cell and molecular biology · 2026Review
- Clinical application research on the titanium metal metatarsal prosthesis designed through FEA and manufactured by 3D printing.Scientific reports · 2025Article
- Individuals with heterogenous trabecular bone texture by clinical magnetic resonance imaging have lower bone strength and stiffness by quantitative computed tomography-based finite element analysis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Potential endpoints for assessment of bone health in persons with neurofibromatosis type 1.Clinical trials (London, England) · 2024Review
- A deep learning-based approach to automatic proximal femur segmentation in quantitative CT images.Medical & biological engineering & computing · 2022Review
- An experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale.Scientific reports · 2021Article
- A finite element analysis of relationship between fracture, implant and tibial tunnel.Scientific reports · 2021Article
- Review
- A Contemporary View of the Diagnosis of Osteoporosis in Patients With Axial Spondyloarthritis.Frontiers in medicine · 2020Review
- Patient-Specific Bone Multiscale Modelling, Fracture Simulation and Risk Analysis-A Survey.Materials (Basel, Switzerland) · 2019Review
- Genetic Dissection of Femoral and Tibial Microarchitecture.JBMR plus · 2019Article
- Perspectives on Sharing Models and Related Resources in Computational Biomechanics Research.Journal of biomechanical engineering · 2018Article
- Vertebral Imaging in the Diagnosis of Osteoporosis: a Clinician's Perspective.Current osteoporosis reports · 2017Review
- In vivo Visualisation and Quantification of Bone Resorption and Bone Formation from Time-Lapse Imaging.Current osteoporosis reports · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beyond bone mineral density (BMD), bone quality designates the mechanical integrity of bone tissue. In vivo images based on X-ray attenuation, such as CT reconstructions, provide size, shape, and local BMD distribution and may be exploited as input for finite element analysis (FEA) to assess bone fragility. Further key input parameters of FEA are the material properties of bone tissue. This review discusses the main determinants of bone mechanical properties and emphasizes the added value, as well as the important assumptions underlying finite element analysis. Bone tissue is a sophisticated, multiscale composite material that undergoes remodeling but exhibits a rather narrow band of tissue mineralization. Mechanically, bone tissue behaves elastically under physiologic loads and yields by cracking beyond critical strain levels. Through adequate cell-orchestrated modeling, trabecular bone tunes its mechanical properties by volume fraction and fabric. With proper calibration, these mechanical properties may be incorporated in quantitative CT-based finite element analysis that has been validated extensively with ex vivo experiments and has been applied increasingly in clinical trials to assess treatment efficacy against osteoporosis.
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Registered trials
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