Evidence map›Paper›PMID 27714565›Full record

ArticleJournal of clinical immunology2016

Asthma and Hypogammaglobulinemia: an Asthma Phenotype with Low Type 2 Inflammation.

Clairelyne Dupin, Sylvain Marchand-Adam, Olivier Favelle, Romain Costes, Philippe Gatault, Philippe Diot, Leslie Grammatico-Guillon, Laurent Guilleminault

Abstract read
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In one paragraph

Article in Journal of clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. How can we minimise the use of regular oral corticosteroids in asthma?European respiratory review : an official journal of the European Respiratory Society · 2020
    Review
  5. [Infection and asthma].Open respiratory archives
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Clairelyne DupinCHRU Tours, Service de Pneumologie et explorations fonctionnelles respiratoires, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, F-37044, Tours Cedex, France.
Sylvain Marchand-AdamCHRU Tours, Service de Pneumologie et explorations fonctionnelles respiratoires, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, F-37044, Tours Cedex, France.
Olivier FavelleCHRU Tours, Groupement d'imagerie médicale, F-37044, Tours, France.
Romain CostesCHRU Tours, service d'information médicale, d'épidémiologie et d'économie de la santé, F-37044, Tours, France.
Philippe GataultCHRU Tours, Service de néphrologie, F-37044, Tours, France.
Philippe DiotCHRU Tours, Service de Pneumologie et explorations fonctionnelles respiratoires, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, F-37044, Tours Cedex, France.
Leslie Grammatico-GuillonCHRU Tours, service d'information médicale, d'épidémiologie et d'économie de la santé, F-37044, Tours, France.
Laurent GuilleminaultCHRU Tours, Service de Pneumologie et explorations fonctionnelles respiratoires, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, F-37044, Tours Cedex, France. guillel@free.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLittle is known about hypogammaglobulinemia (HGG) in asthma patients. No data are available on the characteristics of adult patients with asthma and HGG.

methodsWe conducted a retrospective monocentric study between January 2006 and December 2012. Asthma patients with a serum immunoglobulin (Ig) quantitative analysis were included and classified into two groups depending on their serum IgG concentration: presence or absence of HGG. Clinical, biological, functional, and radiologic characteristics were compared in univariate and multivariate analysis, using a logistic regression model.

resultsIn univariate analysis, asthma patients with HGG (n = 25) were older (58 years old ± 18 vs 49 ± 18, p = 0.04) and more frequently active or former smokers as compared to patients with normoglobulinemia (n = 80) (56.0 vs 35.0 %, p = 0.01). Total IgE < 30 kUI/L was more frequently observed in patients with HGG (53.0 vs 18.3 %, p = 0.01). HGG asthma patients had lower fraction of exhaled nitric oxide (p = 0.02), blood eosinophilia (p = 0.0009), and presented with more severe composite score for bronchiectasis (p = 0.01). In multivariate analysis, asthma patients with HGG had increased risk of being smokers [OR = 6.11 (IC 95 % = 1.16-32.04)], having total IgE concentration < 30 kUI/L [OR = 12.87 (IC 95 % = 2.30-72.15)], and a more severe composite score of bronchiectasis [OR = 20.65 (IC 95 % = 2.13-199.74)].

conclusionAsthma patients with HGG are older and more often tobacco smoker than asthma patients without HGG. These patients have low type-2 inflammation markers.

Indexed as

AgammaglobulinemiaAsthmaBiomarkersFemaleHumansImmunoglobulin EImmunoglobulin GInflammationMaleMiddle AgedPhenotypeRetrospective StudiesRisk FactorsBiomarkersImmunoglobulin EImmunoglobulin Gasthmahypogammaglobulinemiaimmunoglobulin Ginflammation

Identifiers

PMID27714565

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.