ArticleAmino acids2017
Human splanchnic amino-acid metabolism.
Article in Amino acids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Acute Effects of Oral Microbial Protease Co-ingestion with Whey Protein on Postprandial Plasma Amino Acid Concentrations, Appetite, and Satiety in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial.The Journal of nutrition · 2025Trial
- Article
- SLC7 transporters at the crossroads of amino acid metabolism and diabetes pathophysiology: insights and therapeutic perspectives.Frontiers in nutrition · 2025Review
- Origin and Roles of Alanine and Glutamine in Gluconeogenesis in the Liver, Kidneys, and Small Intestine under Physiological and Pathological Conditions.International journal of molecular sciences · 2024Review
- Arginine concentration in arterial vs venous blood in a bleomycin-induced lung inflammation model in mice.PloS one · 2023Article
- Impaired Amino Acid Metabolism and Its Correlation with Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus.Nutrients · 2022Article
- Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs.Porcine health management · 2022Article
- Measuring Protein Turnover in the Field: Implications for Military Research.Advances in nutrition (Bethesda, Md.) · 2021Review
- Evaluation of Analytes Characterized with Potential Protective Action after Rat Exposure to Lead.Molecules (Basel, Switzerland) · 2021Article
- Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans.Frontiers in pharmacology · 2021Article
- Dynamic PET/CT imaging ofEuropean journal of nuclear medicine and molecular imaging · 2020Article
- Pharmacokinetics of oral l-serine supplementation in a single patient.Molecular genetics and metabolism reports · 2020Article
- Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations.Diabetology & metabolic syndrome · 2020Article
- Absorptive transport of amino acids by the rat colon.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Citrulline Generation Test: What Does It Measure?JPEN. Journal of parenteral and enteral nutrition · 2019Article
- Gas chromatography-time of flight/mass spectrometry-based metabonomics of changes in the urinary metabolic profile in osteoarthritic rats.Experimental and therapeutic medicine · 2018Article
- Amino acid homeostasis and signalling in mammalian cells and organisms.The Biochemical journal · 2017Review
- Hepatic metabolism ofAmerican journal of nuclear medicine and molecular imaging · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma levels of several amino acids are correlated with metabolic dysregulation in obesity and type 2 diabetes. To increase our understanding of human amino-acid metabolism, we aimed to determine splanchnic interorgan amino-acid handling. Twenty patients planned to undergo a pylorus preserving pancreatico-duodenectomy were included in this study. Blood was sampled from the portal vein, hepatic vein, superior mesenteric vein, inferior mesenteric vein, splenic vein, renal vein, and the radial artery during surgery. The difference between arterial and venous concentrations of 21 amino acids was determined using liquid chromatography as a measure of amino-acid metabolism across a given organ. Whereas glutamine was significantly taken up by the small intestine (121.0 ± 23.8 µmol/L; P < 0.0001), citrulline was released (-36.1 ± 4.6 µmol/L; P < 0.0001). This, however, was not seen for the colon. Interestingly, the liver showed a small, but a significant uptake of citrulline from the circulation (4.8 ± 1.6 µmol/L; P = 0.0138) next to many other amino acids. The kidneys showed a marked release of serine and alanine into the circulation (-58.0 ± 4.4 µmol/L and -61.8 ± 5.2 µmol/L, P < 0.0001), and a smaller, but statistically significant release of tyrosine (-12.0 ± 1.3 µmol/L, P < 0.0001). The spleen only released taurine (-9.6 ± 3.3 µmol/L; P = 0.0078). Simultaneous blood sampling in different veins provides unique qualitative and quantitative information on integrative amino-acid physiology, and reveals that the well-known intestinal glutamine-citrulline pathway appears to be functional in the small intestine but not in the colon.
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