ArticleJournal of bone and mineral metabolism2017
Lithium chloride enhances bone regeneration and implant osseointegration in osteoporotic conditions.
Article in Journal of bone and mineral metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Tideglusib accelerates bone-tendon interface healing and improves mechanical strength in a rabbit rotator cuff tear model: an experimental study.Journal of orthopaedic surgery and research · 2026Article
- Association Between Lithium Use and Periprosthetic Fracture After Total Hip Arthroplasty.Arthroplasty today · 2025Article
- Synthesis and Osteoinductive Properties of Nanosized Lithium-Modified Calcium-Organic Frameworks.Materials (Basel, Switzerland) · 2025Article
- Lithium chloride stimulates bone formation in extraction socket repair in rats.Oral and maxillofacial surgery · 2024Article
- Laponite intercalated biomimetic multilayer coating prevents glucocorticoids induced orthopedic implant failure.Bioactive materials · 2023Article
- Effect of chronic lithium on mechanical sensitivity and trabecular bone loss induced by type-1 diabetes mellitus in mice.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine.Journal of functional biomaterials · 2022Review
- Physiological Mineralization during In Vitro Osteogenesis in a Biomimetic Spheroid Culture Model.Cells · 2022Article
- Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy.Bioactive materials · 2021Article
- Biomechanics of Implant Fixation in Osteoporotic Bone.Current osteoporosis reports · 2020Review
- Lithium chloride assuages bone loss in experimental periodontitis in estrogen-deficient rats.Clinical oral investigations · 2020Article
- The Skeletal-Protecting Action and Mechanisms of Action for Mood-Stabilizing Drug Lithium Chloride: Current Evidence and Future Potential Research Areas.Frontiers in pharmacology · 2020Review
- Enhancing osseointegration of titanium implants through large-grit sandblasting combined with micro-arc oxidation surface modification.Journal of materials science. Materials in medicine · 2019Article
- Possible Pharmacodynamic and Pharmacokinetic Drug-Drug Interactions That Are Likely to Be Clinically Relevant and/or Frequent in Bipolar Disorder.Current psychiatry reports · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Osteoporotic patients have a high risk of dental and orthopedic implant failure. Lithium chloride (LiCl) has been reported to enhance bone formation. However, the role of LiCl in the success rate of dental and orthopedic implants in osteoporotic conditions is still unknown. We investigated whether LiCl enhances implant osseointegration, implant fixation, and bone formation in osteoporotic conditions. Sprague-Dawley female rats (n = 18) were ovariectomized (OVX) to induce osteoporosis, and another nine rats underwent sham surgery. Three months after surgery, titanium implants were implanted in the tibia of the OVX and sham group rats. After implantation, the OVX rats were gavaged with 150 mg/kg/2 days of LiCl (OVX + LiCl group) or saline (OVX group), and sham group rats were gavaged with saline for 3 months. Implant osseointegration and bone formation were analyzed using histology, biomechanical testing, and micro computed tomography (micro-CT). More bone loss was observed in the OVX group compared to the control, and LiCl treatment enhanced bone formation and implant fixation in osteoporotic rats. In the OVX group, bone-implant contact (BIC) was decreased by 81.2 % compared to the sham group. Interestingly, the OVX + LiCl group showed 4.4-fold higher BIC compared to the OVX group. Micro-CT data of tibia from the OVX + LiCl group showed higher bone volume, trabecular thickness, trabecular number, and osseointegration compared to the OVX group. Maximum push-out force and implant-bone interface shear strength were 2.9-fold stronger in the OVX + LiCl group compared to the OVX group. In conclusion, LiCl enhanced implant osseointegration, implant fixation, and bone formation in osteoporotic conditions, suggesting LiCl as a promising therapeutic agent to prevent implant failure and bone loss in osteoporotic conditions.
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