Evidence map›Paper›PMID 27714255›Full record

ArticleOrganic & biomolecular chemistry2016

Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors.

Ji-Tian Liu, Truman J Do, Christopher J Simmons, John C Lynch, Wen Gu, Zhi-Xiong Ma, Wei Xu, Weiping Tang

Open access · greenAbstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Structural Requirements of Benzofuran Derivatives Dehydro-International journal of molecular sciences · 2020
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ji-Tian LiuSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA and School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, P. R. China.
Truman J DoMcArdle Laboratory for Cancer Research, Wisconsin Institute for Medical Research, University of Wisconsin-Madison, Madison, WI 53705, USA.
Christopher J SimmonsSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA and Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
John C LynchSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.
Wen GuSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA and Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Zhi-Xiong MaMedicinal Chemistry Center, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53706, USA. wtang@pharmacy.wisc.edu.
Wei XuMcArdle Laboratory for Cancer Research, Wisconsin Institute for Medical Research, University of Wisconsin-Madison, Madison, WI 53705, USA.
Weiping TangSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA and Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA and Medicinal Chemistry Center, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53706, USA. wtang@pharmacy.wisc.edu.
Madison Group (United States) · USUniversity of Wisconsin–Madison · USCenter for Cancer Research · USNanjing Forestry University · CN

Funding

Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MACOSKA, JILL A., MARKER, PAUL C · 2014 to 2023
$12.8M
NIDDK NIH HHS U54 DK104310
6 · The paper itself

Abstract

We have developed a versatile synthetic strategy for the synthesis of the natural product diptoindonesin G and its analogues as selective modulators of estrogen receptors. The strategy involves a regioselective dehydrative cyclization of arylacetals, a regioselective bromination of benzofurans, a sequential cross-coupling of bromo-benzofurans with aryl boronic acids, and a BBr

Indexed as

AcetalsBenzofuransBoronic AcidsCyclizationHalogenationHumansMCF-7 CellsProtein StabilityReceptors, EstrogenStereoisomerismAcetalsBenzofuransBoronic Acidsdiptoindonesin GReceptors, Estrogen

Identifiers

PMID27714255
PMCPMC7244339
OpenAlexW2518941014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.