ReviewTremor and other hyperkinetic movements (New York, N.Y.)2016
Orthostatic Tremor: An Update on a Rare Entity.
Review in Tremor and other hyperkinetic movements (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Clinical and Electrophysiological Heterogeneity of Orthostatic Tremor: An Individual Patient Data Analysis.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Pooled it
- Slow Orthostatic Tremor: Review of the Current Evidence.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Orthostatic tremor and its subtypes: a single centre cohort of 74 patients.Journal of neurology · 2026Article
- Longitudinal Orthostatic Tremor Study (LOTS): a multi-centre, prospective cohort protocol for characterising orthostatic tremor and orthostatic myoclonus.BMJ neurology open · 2026Article
- Increased susceptibility and volume reduction in deep brain nuclei in primary orthostatic tremor.BMJ neurology open · 2026Article
- Multidimensional Phenotyping of Orthostatic Tremor and Orthostatic Myoclonus: Baseline Findings from a Longitudinal Clinical Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Orthostatic Hyperkinetic Disorders in Subacute Sclerosing Panencephalitis - A Novel Observation.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Differential diagnosis of orthostatic dizziness with persistent postural-perceptual dizziness and its underlying mechanisms.Frontiers in neurology · 2025Review
- Effect of Orthostatic Tremor on Quality of Life - a Cohort Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Measurement of Functional Brain Network Connectivity in People with Orthostatic Tremor.Brain sciences · 2024Article
- Pseudo-Orthostatic Tremor in Graves' Disease: A Possible Early Sign of Parkinsonism?Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Consensus Paper: Ataxic Gait.Cerebellum (London, England) · 2023Article
- Electrophysiological Characterization of aMovement disorders clinical practice · 2023Article
- Orthostatic tremor after knee contusion without head trauma: A rare case report.Turkish journal of physical medicine and rehabilitation · 2023Article
- Dutch translation, adaptation and validation of the OT-10 scale for orthostatic tremor.Clinical parkinsonism & related disorders · 2023Article
- Mild hyperphenylalaninemia (hpa) presenting as orthostatic tremor: a case report.BMC neurology · 2022Article
- The Phenomenology of Primary Orthostatic Tremor.Movement disorders clinical practice · 2022Article
- Primary orthostatic tremor and orthostatic tremor-plus in dogs: 60 cases (2003-2020).Journal of veterinary internal medicine · 2022Article
- Diagnosis of orthostatic tremor using smartphone accelerometry.BMC neurology · 2021Article
- A Chinese case of fragile X-associated tremor/ataxia syndrome (FXTAS) with orthostatic tremor:case report and literature review on tremor in FXTAS.BMC neurology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOrthostatic tremor (OT) remains among the most intriguing and poorly understood of movement disorders. Compared to Parkinson's disease or even essential tremor, there are very few articles addressing more basic science issues. In this review, we will discuss the findings of main case series on OT, including data on etiology, pathophysiology, diagnostic approach, treatment strategies, and outcome.
methodsData for this review were identified by searching PUBMED (January 1966 to August 2016) for the terms "orthostatic tremor" or "shaky leg syndrome," which yielded 219 entries. We did not exclude papers on the basis of language, country, or publication date. The electronic database searches were supplemented by articles in the authors' files that pertained to this topic.
resultsOwing to its rarity, the current understanding of OT is limited and is mostly based on small case series or case reports. Despite this, a growing body of evidence indicates that OT might be a progressive condition that is clinically heterogeneous (primary vs. secondary cases) with a broader spectrum of clinical features, mainly cerebellar signs, and possible cognitive impairment and personality disturbances. Along with this, advanced neuroimaging techniques are now demonstrating distinct anatomical and functional changes, some of which are consistent with neuronal loss. DISCUSSION: OT might be a family of diseases, unified by the presence of leg tremor, but further characterized by etiological and clinical heterogeneity. More work is needed to understand the pathogenesis of this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.