ArticlePharmacology research & perspectives2016
Frequency and trends of disease-modifying antirheumatic drug (DMARD) use in Germany.
Article in Pharmacology research & perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Rituximab plus leflunomide in rheumatoid arthritis: a randomized, placebo-controlled, investigator-initiated clinical trial (AMARA study).Rheumatology (Oxford, England) · 2021Trial
- Large-Scale Postmarketing Surveillance of Biological Drugs for Immune-Mediated Inflammatory Diseases Through an Italian Distributed Multi-Database Healthcare Network: The VALORE Project.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2021Article
- Prescribing Trends of Biologic Disease-Modifying Anti-rheumatic Drugs Using a Claims Database from 6 Million People in Japan.Clinical drug investigation · 2021Article
- Management of Rheumatoid Arthritis: An Overview.Cells · 2021Review
- Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study.Rheumatology (Oxford, England) · 2018Article
- [Outpatient care and disease burden of rheumatoid arthritis : Results of a linkage of claims data and a survey of insured persons].Zeitschrift fur Rheumatologie · 2018Article
- Frequency and trends of disease-modifying antirheumatic drug (DMARD) use in Germany.Pharmacology research & perspectives · 2016Article
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3 authors.
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Abstract
The aim of this study was to analyze the population-based frequency of classic (c-) and biologic (b-) disease-modifying antirheumatic drug (DMARD) use over time, selected underlying indications and the specialty of the prescribing physicians in Germany. Based on the claims data of the German Pharmacoepidemiological Research Database (GePaRD), yearly cross-sectional studies were conducted from 2004 to 2011. The prevalence of DMARD use was calculated as the number of persons with at least one dispensation per 1000 persons stratified by sex and age. In 2011, we also obtained the proportion of c- and b-DMARDs users with diagnoses of selected indications and the proportion of dispensations by specialty of the physician. Between 2004 and 2011, the annual prevalence of b-DMARD and c-DMARD use increased from 0.35‰ to 1.54‰ and from 6.53‰ to 8.93‰, respectively. In 2011, the study population comprised 12.8 million insurants with a mean age of 44.0 years. During this year, among c-DMARDs, methotrexate was prescribed most frequently (4.76‰), followed by azathioprine (1.72‰) and sulfasalazine (1.20‰). For b-DMARDs, adalimumab (0.57‰), etanercept (0.46‰), and rituximab (0.23‰) were most frequently used. Notably, b-DMARD users more often had a diagnosis of ankylosing spondylitis and psoriasis compared to c-DMARD-users (20.7% vs. 2.9% and 20.0% vs. 11.4%, respectively) and b-DMARDs were more frequently prescribed by rheumatologists and other specialists. Our population-based study highlights the increasing use of c- and b-DMARDs in Germany. Compared to c-DMARDs, b-DMARDs were commonly used for indications besides rheumatoid arthritis. Future research should therefore also focus on their prescription patterns and safety aspects in indications other than RA.
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