Evidence map›Paper›PMID 27713824›Full record

ArticlePharmacology research & perspectives2016

Comparison of [

Hui Liu, Hongjun Jin, Xuyi Yue, Junbin Han, Hao Yang, Hubert Flores, Yi Su, David Alagille, Joel S Perlmutter, Gilles Tamagnan and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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  7. In Vivo Characterization of TwoACS chemical neuroscience · 2018
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  8. Comparison of [Pharmacology research & perspectives · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hui LiuDepartment of Radiology Washington University School of Medicine St. Louis Missouri.
Hongjun JinDepartment of Radiology Washington University School of Medicine St. Louis Missouri.
Xuyi YueDepartment of Radiology Washington University School of Medicine St. Louis Missouri.
Junbin HanDepartment of Radiology Washington University School of Medicine St. Louis Missouri.
Hao YangDepartment of Radiology Washington University School of Medicine St. Louis Missouri.
Hubert FloresDepartment of Neurology Washington University School of Medicine St. Louis Missouri.
Yi SuDepartment of Radiology Washington University School of Medicine St. Louis Missouri.
David AlagilleMolecular NeuroImaging LLC New Haven Connecticut.
Joel S PerlmutterDepartment of Radiology Washington University School of Medicine St. Louis Missouri; Department of Neurology Washington University School of Medicine St. Louis Missouri; Department of Neuroscience Physical Therapy and Occupational Therapy Washington University School of Medicine St. Louis Missouri.
Gilles TamagnanMolecular NeuroImaging LLC New Haven Connecticut.
Zhude TuDepartment of Radiology Washington University School of Medicine St. Louis Missouri.
Washington University in St. Louis · USElucid Bioimaging · US

Funding

PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)R33MH092797 · NIMH · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2013 to 2015
$1.5M
DEVELOPMENT OF VESICULAR ACETYLCHOLINE TRANSPORTER IMAGING AGENTS FOR PETR21NS061025 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2009 to 2010
$628k
DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)R21MH092797 · NIMH · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2012
$530k
NIMH NIH HHS R21 MH092797NIMH NIH HHS R33 MH092797NINDS NIH HHS R01 NS075527NINDS NIH HHS R21 NS061025
6 · The paper itself

Abstract

Phosphodiesterase 10A (PDE10A) inhibitors show therapeutic effects for diseases with striatal pathology. PET radiotracers have been developed to quantify in vivo PDE10A levels and target engagement for therapeutic interventions. The aim of this study was to compare two potent and selective PDE10A radiotracers, [

Indexed as

Comparisonnonhuman primatesPDE10APET radiotracertracer kineticstracer metabolismtracer uptake

Identifiers

PMID27713824
PMCPMC5045939
OpenAlexW2510005259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.