Evidence map›Paper›PMID 27713821›Full record

ArticlePharmacology research & perspectives2016

RGS14 regulates the lifetime of G

Nicole E Brown, Nevin A Lambert, John R Hepler

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. RGS14 regulates the lifetime of GPharmacology research & perspectives · 2016
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nicole E BrownDepartment of Pharmacology Emory University School of Medicine Atlanta Georgia 30322.
Nevin A LambertDepartment of Pharmacology and Toxicology Medical College of Georgia at Augusta University Augusta Georgia 30912.
John R HeplerDepartment of Pharmacology Emory University School of Medicine Atlanta Georgia 30322.
Emory University · USAugusta University · US

Funding

Structure and Function of the G-alpha-i1:RGS14:H-Ras signaling complexR01NS037112 · NINDS · EMORY UNIVERSITY · PI HEPLER, JOHN R · 1998 to 2023
$7.2M
Graduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1M
GPCR signaling complexes in living cellsR01GM078319 · NIGMS · AUGUSTA UNIVERSITY · PI LAMBERT, NEVIN ALAN · 2007 to 2017
$2.1M
Single-molecule and ensemble imaging of GPCR-G protein complexes in live cellsR01GM109879 · NIGMS · AUGUSTA UNIVERSITY · PI JAVITCH, JONATHAN A, LAMBERT, NEVIN ALAN · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM078319NIGMS NIH HHS R01 GM109879NIGMS NIH HHS T32 GM008602NINDS NIH HHS R01 NS037112
6 · The paper itself

Abstract

RGS14 is a multifunctional scaffolding protein possessing two distinct G protein interaction sites including a regulator of G protein signaling (RGS) domain that acts as a GTPase activating protein (GAP) to deactivate G

Indexed as

GPCRG proteinGαi1GβγRGS14.RGS protein

Identifiers

PMID27713821
PMCPMC5045935
OpenAlexW2508899024

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.