Evidence map›Paper›PMID 27713633›Full record

Trial reportVascular health and risk management2016

Comparison of the acute-phase response after laparoscopic versus open aortobifemoral bypass surgery: a substudy of a randomized controlled trial.

Anne H Krog, Mehdi Sahba, Erik M Pettersen, Irene Sandven, Per M Thorsby, Jørgen J Jørgensen, Jon O Sundhagen, Syed Ss Kazmi

Erratum issuedOpen access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Vascular health and risk management, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Anne H KrogInstitute of Clinical Medicine, University of Oslo; Department of Vascular Surgery, Division of Cardiovascular and Pulmonary Diseases, Oslo University Hospital, Oslo.
Mehdi SahbaDepartment of Vascular Surgery, Østfold Central Hospital, Fredrikstad.
Erik M PettersenDepartment of Vascular Surgery, Sørlandet Hospital HF, Kristiansand.
Irene SandvenOslo Center for Biostatistics and Epidemiology (OCBE).
Per M ThorsbyInstitute of Clinical Medicine, University of Oslo; Hormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Jørgen J JørgensenInstitute of Clinical Medicine, University of Oslo; Department of Vascular Surgery, Division of Cardiovascular and Pulmonary Diseases, Oslo University Hospital, Oslo.
Jon O SundhagenDepartment of Vascular Surgery, Division of Cardiovascular and Pulmonary Diseases, Oslo University Hospital, Oslo.
Syed Ss KazmiDepartment of Vascular Surgery, Division of Cardiovascular and Pulmonary Diseases, Oslo University Hospital, Oslo.
Oslo University Hospital · NOØstfold Hospital Trust · NOSørlandet Sykehus · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMinimally invasive surgical techniques have been shown to reduce the inflammatory response related to a surgical procedure. The main objective of our study was to measure the inflammatory response in patients undergoing a totally laparoscopic versus open aortobifemoral bypass surgery. This is the first randomized trial on subjects in this population. PATIENTS AND

methodsThis is a substudy of a larger randomized controlled multicenter trial (Norwegian Laparoscopic Aortic Surgery Trial). Thirty consecutive patients with severe aortoiliac occlusive disease eligible for aortobifemoral bypass surgery were randomized to either a totally laparoscopic (n=14) or an open surgical procedure (n=16). The inflammatory response was measured by perioperative monitoring of serum interleukin-6 (IL-6), IL-8, and C-reactive protein (CRP) at six different time points.

resultsThe inflammatory reaction caused by the laparoscopic procedure was reduced compared with open surgery. IL-6 was significantly lower after the laparoscopic procedure, measured by comparing area under the curve (AUC), and after adjusting for the confounding effect of coronary heart disease (

conclusionIn this substudy of a randomized controlled trial comparing laparoscopic and open aortobifemoral bypass surgeries, we found a decreased perioperative inflammatory response after the laparoscopic procedure measured by comparing AUC for serum IL-6.

Indexed as

Acute-Phase ReactionAgedAortic DiseasesArterial Occlusive DiseasesBiomarkersConstriction, PathologicC-Reactive ProteinFemaleHumansIliac ArteryInflammation MediatorsInterleukin-6Interleukin-8LaparoscopyMaleMiddle AgedBiomarkersC-Reactive ProteinCXCL8 protein, humanIL6 protein, humanInflammation MediatorsInterleukin-6Interleukin-8C-reactive proteininflammationinterleukinlaparoscopysurgeryvascular

Identifiers

PMID27713633
PMCPMC5045228
OpenAlexW2524368804

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.