ArticleInternational journal of chronic obstructive pulmonary disease2016
Can resistive breathing injure the lung? Implications for COPD exacerbations.
Article in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Loss of Iron Regulatory Protein 2 Protects Mice from Lung Inflammation during Bronchoconstriction.American journal of respiratory cell and molecular biology · 2025Article
- Resistive breathing aggravates cigarette smoke-induced pulmonary inflammation.ERJ open research · 2025Article
- Resistive spontaneous breathing exacerbated lipopolysaccharide-induced lung injury in mice.Biochemistry and biophysics reports · 2024Article
- Synergistic Effects of Resistive Breathing on Endotoxin-Induced Lung Injury in Mice.International journal of chronic obstructive pulmonary disease · 2023Article
- Spontaneous Breathing Through Increased Airway Resistance Augments Elastase-Induced Pulmonary Emphysema.International journal of chronic obstructive pulmonary disease · 2020Article
- p38 Inhibition Ameliorates Inspiratory Resistive Breathing-Induced Pulmonary Inflammation.Inflammation · 2018Article
- The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammation.Respiratory research · 2017Article
- Tiotropium bromide exerts anti-inflammatory effects during resistive breathing, an experimental model of severe airway obstruction.International journal of chronic obstructive pulmonary disease · 2017Article
- TRPV4 Inhibition Exerts Protective Effects Against Resistive Breathing Induced Lung Injury.International journal of chronic obstructive pulmonary diseaseArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In obstructive lung diseases, airway inflammation leads to bronchospasm and thus resistive breathing, especially during exacerbations. This commentary discusses experimental evidence that resistive breathing per se (the mechanical stimulus) in the absence of underlying airway inflammation leads to lung injury and inflammation (mechanotransduction). The potential implications of resistive breathing-induced mechanotrasduction in COPD exacerbations are presented along with the available clinical evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.