Evidence map›Paper›PMID 27713589›Full record

ArticleTetrahedron letters2016

Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC.

Mark E Petersen, Noemi Kedei, Nancy E Lewin, Peter M Blumberg, Gary E Keck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark E PetersenUniversity of Utah, Department of Chemistry, Salt Lake City, UT, 84112, USA.
Noemi KedeiLaboratory of Cancer Biology and Genetics, NCI, National Institutes of Health, Bethesda, MD 20892-4255, USA.
Nancy E LewinLaboratory of Cancer Biology and Genetics, NCI, National Institutes of Health, Bethesda, MD 20892-4255, USA.
Peter M BlumbergLaboratory of Cancer Biology and Genetics, NCI, National Institutes of Health, Bethesda, MD 20892-4255, USA.
Gary E KeckUniversity of Utah, Department of Chemistry, Salt Lake City, UT, 84112, USA.

Funding

Molecular Mechanism of Action of Phorbol EsterZIABC005270 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BLUMBERG, PETER · 2009 to 2018
$18.4M
CHIRAL APPROACHES TO NATURAL PRODUCT SYNTHESISR01GM028961 · NIGMS · UNIVERSITY OF UTAH · PI KECK, GARY E · 1985 to 2014
$5.5M
MOLECULAR MECHANISM OF ACTION OF PHORBOL ESTER TUMOR PROMOTERSZ01BC005270 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BLUMBERG, PETER · 1996 to 2008
$4.3M
Intramural NIH HHS Z01 BC005270NIGMS NIH HHS R01 GM028961United States NIGMS
6 · The paper itself

Abstract

We describe a convergent synthesis of a bryostatin analogue in which the natural A- and B-ring pyrans have been replaced by phenyl rings. The new analogue exhibited PMA like behavior in cell assays, but failed to maintain high affinity binding for PKC, despite retaining an unaltered C-ring 'binding domain'.

Indexed as

analoguesBryostatinCross couplingHeck reactionPKCSAR

Identifiers

PMID27713589
PMCPMC5047013

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.