ArticleScientific reports2016
Identifying molecular signatures of hypoxia adaptation from sex chromosomes: A case for Tibetan Mastiff based on analyses of X chromosome.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Genomic signals on the X chromosome reveal local adaptations in Ethiopian cattle.BMC genomics · 2026Article
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- Genomic evidence of improved fertility and adaptation in Iranian domestic sheep attributed to introgression from Asiatic Mouflon and urial.Scientific reports · 2025Article
- Physiological and Genetic Basis of High-Altitude Indigenous Animals' Adaptation to Hypoxic Environments.Animals : an open access journal from MDPI · 2024Review
- Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau.BMC biology · 2023Article
- Transcriptome analysis provides new insights into cold adaptation of corsac fox (Ecology and evolution · 2022Article
- Identification of Selection Signals on the X-Chromosome in East Adriatic Sheep: A New Complementary Approach.Frontiers in genetics · 2022Article
- Comparison of a NewCells · 2021Article
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- Deciphering the puzzles of dog domestication.Zoological research · 2020Review
- Genomic signatures of high-altitude adaptation in Ethiopian sheep populations.Genes & genomics · 2019Article
- Convergent evolution in human and domesticate adaptation to high-altitude environments.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health.National science review · 2019Article
- Early prediction of revascularisation by angiomotin-targeting positron emission tomography.Theranostics · 2018Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide studies on high-altitude adaptation have received increased attention as a classical case of organismal evolution under extreme environment. However, the current genetic understanding of high-altitude adaptation emanated mainly from autosomal analyses. Only a few earlier genomic studies paid attention to the allosome. In this study, we performed an intensive scan of the X chromosome of public genomic data generated from Tibetan Mastiff (TM) and five other dog populations for indications of high-altitude adaptation. We identified five genes showing signatures of selection on the X chromosome. Notable among these genes was angiomotin (AMOT), which is related to the process of angiogenesis. We sampled additional 11 dog populations (175 individuals in total) at continuous altitudes in China from 300 to 4,000 meters to validate and test the association between the haplotype frequency of AMOT gene and altitude adaptation. The results suggest that AMOT gene may be a notable candidate gene for the adaptation of TM to high-altitude hypoxic conditions. Our study shows that X chromosome deserves consideration in future studies of adaptive evolution.
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