ArticleScientific reports2016
Metabolomics of aging assessed in individual parasitoid wasps.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- The hallmarks of protein and amino acid restriction in aging and longevity.Cell press blue · 2026Article
- Comparative metabolomics reveal developmental and ecological plasticity in the invasive parasite Philornis downsi (Diptera: Muscidae) from the Galapagos Islands.Journal of insect science (Online) · 2026Article
- Courtship Is a Major Factor of Mating-Shortened Male Lifespan in an Egg Parasitoid.Ecology and evolution · 2025Article
- Widely Targeted HPLC-MS/MS Metabolomics Analysis Reveals Natural Metabolic Insights in Insects.Metabolites · 2023Article
- Article
- Comparative Metabolomic Study ofInternational journal of molecular sciences · 2021Article
- Beyond Sperm and Male Accessory Gland Proteins: Exploring Insect Reproductive Metabolomes.Frontiers in physiology · 2021Review
- A procession of metabolic alterations accompanying muscle senescence in Manduca sexta.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Metabolomics studies of low-biomass organisms, such as small insects, have previously relied on the pooling of biological samples to overcome detection limits, particularly using NMR. We show that the differentiation of metabolite profiles of individual 1 mg parasitoid wasps of different ages is possible when using a modified sample preparation and a combination of untargeted NMR and LC-MS based metabolomics. Changes were observed between newly emerged and older wasps in glycerolipids, amino acids and circulatory sugars. This advance in chemical profiling has important implications for the study of the behaviour and ecology of parasitoids and many other species of small organisms because predictions and observations are typically made at the level of the individual. Thus, the metabolomic state of low-biomass individuals can now be related to their behaviour and ecological performance. We discuss specifically the utility of age-related metabolomic profiling but our new approach can be applied to a wide range of biological research.
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Registered trials
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