Evidence map›Paper›PMID 27713503›Full record

ArticleScientific reports2016

Left Atrial trajectory impairment in Hypertrophic Cardiomyopathy disclosed by Geometric Morphometrics and Parallel Transport.

Paolo Piras, Concetta Torromeo, Federica Re, Antonietta Evangelista, Stefano Gabriele, Giuseppe Esposito, Paola Nardinocchi, Luciano Teresi, Andrea Madeo, Claudia Chialastri and 4 more

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  8. Longitudinal trajectories of left ventricular myocardial remodeling: associations with cardiovascular risk factors in the multi-ethnic study of atherosclerosis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Paolo PirasDipartimento di Ingegneria Strutturale e Geotecnica, Sapienza Università di Roma, Roma, Italy.
Concetta TorromeoDipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Roma, Italy.
Federica ReCentro per le Cardiomiopatie Ospedale S. Camillo-Forlanini, Roma, Italy.
Antonietta EvangelistaOspedale San Giovanni Calibita Fatebenefratelli Isola Tiberina, Roma, Italy.
Stefano GabrieleDipartimento di Architettura, Università Roma Tre, Roma, Italy.
Giuseppe EspositoDipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Roma, Italy.
Paola NardinocchiDipartimento di Ingegneria Strutturale e Geotecnica, Sapienza Università di Roma, Roma, Italy.
Luciano TeresiDipartimento di Matematica e Fisica, LaMS-Modeling &Simulation Lab, Università Roma Tre, Roma, Italy.
Andrea MadeoDipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Roma, Italy.
Claudia ChialastriCentro per le Cardiomiopatie Ospedale S. Camillo-Forlanini, Roma, Italy.
Michele SchiaritiDipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Roma, Italy.
Valerio VaranoDipartimento di Architettura, Università Roma Tre, Roma, Italy.
Massimo UguccioniCentro per le Cardiomiopatie Ospedale S. Camillo-Forlanini, Roma, Italy.
Paolo E PudduDipartimento di Ingegneria Strutturale e Geotecnica, Sapienza Università di Roma, Roma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The analysis of full Left Atrium (LA) deformation and whole LA deformational trajectory in time has been poorly investigated and, to the best of our knowledge, seldom discussed in patients with Hypertrophic Cardiomyopathy. Therefore, we considered 22 patients with Hypertrophic Cardiomyopathy (HCM) and 46 healthy subjects, investigated them by three-dimensional Speckle Tracking Echocardiography, and studied the derived landmark clouds via Geometric Morphometrics with Parallel Transport. Trajectory shape and trajectory size were different in Controls versus HCM and their classification powers had high AUC (Area Under the Receiving Operator Characteristic Curve) and accuracy. The two trajectories were much different at the transition between LA conduit and booster pump functions. Full shape and deformation analyses with trajectory analysis enabled a straightforward perception of pathophysiological consequences of HCM condition on LA functioning. It might be worthwhile to apply these techniques to look for novel pathophysiological approaches that may better define atrio-ventricular interaction.

Indexed as

Models, CardiovascularAdultAtrial Function, LeftCardiomyopathy, HypertrophicCase-Control StudiesEchocardiography, Three-DimensionalFemaleHeart AtriaHumansImaging, Three-DimensionalLinear ModelsMaleMiddle AgedSupport Vector Machine

Identifiers

PMID27713503
PMCPMC5054674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.