ArticleScientific reports2016
Prognostic Value of Reverse Dipper Blood Pressure Pattern in Chronic Kidney Disease Patients not Undergoing Dialysis: Prospective Cohort Study.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03718585 (Whole Exome Sequencing Analysis Project in Chronic Kidney Disease Patients With Nocturnal Hypertension), which is not on this map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Whole Exome Sequencing Analysis Project in Chronic Kidney Disease Patients With Nocturnal Hypertension
Who cites it
19 citing papers in PubMed.
- Loss of Nocturnal Dipping in Type 2 Diabetes Mellitus According to Diabetic Kidney Disease: The Role of Vitamin D Levels.Nutrients · 2026Article
- Effects of reduced blood pressure dipping on the progression of chronic kidney disease in children.BMC pediatrics · 2025Article
- Extreme dipping blood pressure pattern is associated with increased mortality in hemorrhagic stroke patients: a retrospective cohort study.BMC neurology · 2025Article
- [Blood pressure patterns in pressurometry and their ralationship with cardiovascular events in follow-up]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2024Article
- Risk Factors of Chronic Kidney Disease Progression: Between Old and New Concepts.Journal of clinical medicine · 2024Review
- Nocturnal systolic blood pressure dipping and progression of chronic kidney disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Prognostic Value of Nighttime Double Product in Nondialysis Chronic Kidney Disease With Hypertension.Journal of the American Heart Association · 2023Article
- Short-term blood pressure variability as a potential therapeutic target for kidney disease.Clinical hypertension · 2023Review
- Review
- Reduced Blood Pressure Dipping Is A Risk Factor for the Progression of Chronic Kidney Disease in Children.Biomedicines · 2022Article
- Nocturnal heart rate rising is a risk factor for poor renal outcomes in patients with chronic kidney disease and hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2022Observational
- Practical application of ABPM in the pediatric nephrology clinic.Pediatric nephrology (Berlin, Germany) · 2020Review
- Nocturnal blood pressure is associated with sympathetic nerve activity in patients with chronic kidney disease.Physiological reports · 2020Article
- Nocturnal blood pressure changes in Parkinson's disease: correlation with autonomic dysfunction and vitamin D levels.Acta neurologica Belgica · 2020Article
- Ambulatory blood pressure monitoring-based analysis of long-term outcomes for kidney disease progression.Scientific reports · 2019Article
- Nocturnal dipping status and the association of morning blood pressure surge with subclinical target organ damage in untreated hypertensives.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Role and prognostic value of individual ambulatory blood pressure components in chronic kidney disease.Journal of human hypertension · 2018Review
- Renal denervation attenuates hypertension but not salt sensitivity in ETAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Clinical and prognostic significance of a reverse dipping pattern on ambulatory monitoring: An updated review.Journal of clinical hypertension (Greenwich, Conn.) · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "reverse dipping" blood pressure (BP) pattern has been studied among the general population and in individuals suffering from hypertension. However, the prognosis of this pattern in chronic kidney disease (CKD) patients is not known. We monitored BP throughout the day and followed health outcomes in 588 CKD patients admitted to our hospital. Time to all-cause mortality, cardiovascular mortality, renal events and cardiovascular events was recorded. Multivariate-adjusted Cox regression analyses were carried out to detect the prognostic value of a reverse dipping BP pattern. Prevalence of a "dipper", "non-dipper" and "reverse dippers" was 34.69%, 43.54% and 18.03%, respectively. Patients with a reverse dipping pattern had a higher prevalence of total mortality, cardiovascular mortality, renal events and cardiovascular events than patients with a dipping pattern (P < 0.025). Multivariate-adjusted Cox regression analyses showed that reverse dippers (versus dippers) were associated with a higher risk of total mortality (hazard ratio [HR], 5.08; 95% confidence interval [CI], 1.79~14.47), cardiovascular mortality (4.17; 1.25~13.88), renal events (3.00; 1.59~5.65) and cardiovascular events (4.12; 1.78~9.51) even after adjustment by 24-h systolic BP. These data suggest that a reverse dipping BP pattern, independent of 24-h levels of systolic BP, has prognostic value in CKD patients not undergoing dialysis.
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