SynthesisScientific reports2016
A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.Molecular carcinogenesis · 2018Pooled it
- Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.Nature genetics · 2017Pooled it
- Association between the HOTAIR polymorphisms and cancer risk: an updated meta-analysis.Oncotarget · 2017Pooled it
- The Role of lncRNA Polymorphisms in Digestive System Cancers: A Systematic Review and Meta-Analysis.Cancers · 2026Review
- Roles of non-coding RNAs in intercellular crosstalk in cardiovascular diseases.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Review
- Loss of Nexilin function leads to a recessive lethal fetal cardiomyopathy characterized by cardiomegaly and endocardial fibroelastosis.American journal of medical genetics. Part A · 2022Article
- Transcriptional and reverse transcriptional regulation of host genes by human endogenous retroviruses in cancers.Frontiers in microbiology · 2022Review
- Non-Coding Variants in Cancer: Mechanistic Insights and Clinical Potential for Personalized Medicine.Non-coding RNA · 2021Review
- Decoding LncRNAs.Cancers · 2021Review
- 8q24.21 Locus: A Paradigm to Link Non-Coding RNAs, Genome Polymorphisms and Cancer.International journal of molecular sciences · 2021Review
- MHC Class I Regulation: The Origin Perspective.Cancers · 2020Article
- Transcriptome-wide association study reveals candidate causal genes for lung cancer.International journal of cancer · 2020Article
- Long Noncoding RNAs, New Critical Regulators in Cancer Immunity.Frontiers in oncology · 2020Review
- Computational Prediction of Probable Single Nucleotide Polymorphism-Cancer Relationships.Cancer informatics · 2020Article
- Detection of Allosteric Effects of lncRNA Secondary Structures Altered by SNPs in Human Diseases.Frontiers in cell and developmental biology · 2020Article
- LncRNA NEXN-AS1 attenuates proliferation and migration of vascular smooth muscle cells through sponging miR-33a/b.RSC advances · 2019Article
- Correlations between Genetic Polymorphisms in Long Non-Coding RNAInternational journal of molecular sciences · 2019Article
- Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.Carcinogenesis · 2019Article
- Long Noncoding RNACells · 2019Review
- SNPs in LncRNA genes are associated with non-small cell lung cancer in a Chinese population.Journal of clinical laboratory analysis · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 15 institutions in 7 countries.
Hua YuanCollaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Hongliang LiuDepartment of Medicine, Duke University School of Medicine, Durham, NC, USA.
Zhensheng LiuDepartment of Medicine, Duke University School of Medicine, Durham, NC, USA.
Kouros OwzarDuke Cancer Institute, Duke University Medical Center, Durham, NC, USA.
Younghun HanCommunity and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NC, USA.
Li SuMassachusetts General Hospital, Boston, Massachusetts, USA.
Yongyue WeiMassachusetts General Hospital, Boston, Massachusetts, USA.
Rayjean J HungLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
John McLaughlinPublic Health Ontario, Toronto, Ontario, Canada.
Yonathan BrhaneLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Paul BrennanGenetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France.
Heike BickeboellerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
Albert RosenbergerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Neil CaporasoGenetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Maria Teresa LandiGenetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Joachim HeinrichHelmholtz Centre Munich, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany.
Angela RischDepartment of Molecular Biology, University of Salzburg, Salzburg, Austria.
David C ChristianiMassachusetts General Hospital, Boston, Massachusetts, USA.
Zeynep H GümüşDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA.
Robert J KleinDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA.
Christopher I AmosCommunity and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NC, USA.
Qingyi WeiDepartment of Medicine, Duke University School of Medicine, Durham, NC, USA.
Duke Medical Center · USMassachusetts General Hospital · USDartmouth College · USIcahn School of Medicine at Mount Sinai · USLunenfeld-Tanenbaum Research Institute · CAUniversity of Göttingen · DECentre international de recherche sur le cancer · FRDuke University Hospital · USHeidelberg University · DEInstitute of Cancer Research · GBLudwig-Maximilians-Universität München · DENanjing Medical University · CNNational Cancer Institute · USNational Institutes of Health · USPublic Health Ontario · CA
Funding
Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8MTranslational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MUNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V., MINNA, JOHN D. · 1996 to 2024
$57.4MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MTHE CAROTENE AND RETINOL EFFICACY TRIAL (CARET)U01CA063673 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 1994 to 2006
$13.0MTranslational studies of Hsp90 inhibitors in NSCLCP50CA090578 · NCI · DANA-FARBER CANCER INST · PI YEAP, BEOW Y · 2008 to 2012
$11.4MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MGenes contributing to nicotine dependence in humansR01DA017932 · NIDA · DECODE GENETICS, INC. · PI STEFANSSON, KARI · 2005 to 2015
$9.6MPROSTATE, LUNG, COLORECTAL, &OVARIAN CANCER SCREENINGN01CN025476 · CN · WESTAT, INC. · PI O'BRIEN, BARBARA B · 1992 to 2000
$7.9MGenome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6MMolecular and Genetic Analysis of Lung Cancer SurvivalR01CA092824 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 2002 to 2013
$5.9MCancer Research UK C1298/A8362Cancer Research UK C1298/A8780CCR NIH HHS N01 RC037004NCI NIH HHS K07 CA160753NCI NIH HHS N01 CN025404NCI NIH HHS N01 CN025476NCI NIH HHS N01 CN025511NCI NIH HHS N01 CN025512NCI NIH HHS N01 CN025513NCI NIH HHS N01 CN025514NCI NIH HHS N01 CN025515NCI NIH HHS N01 CN025516NCI NIH HHS N01 CN025518NCI NIH HHS N01 CN025522NCI NIH HHS N01 CN025524NCI NIH HHS N01 CN045165NCI NIH HHS N01 CN075022NCI NIH HHS P20 CA090578NCI NIH HHS P30 CA014236NCI NIH HHS P30 CA023108NCI NIH HHS P50 CA070907NCI NIH HHS P50 CA090578NCI NIH HHS R01 CA055769NCI NIH HHS R01 CA074386NCI NIH HHS R01 CA092039NCI NIH HHS R01 CA092824NCI NIH HHS R01 CA111703NCI NIH HHS R01 CA121197NCI NIH HHS R01 CA127219NCI NIH HHS R01 CA133996NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA063673NCI NIH HHS U19 CA148127NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG007033NIDA NIH HHS R01 DA017932Wellcome TrustWorld Health Organization 001
Abstract
Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium in populations of European ancestry. Previously unreported significant SNPs (P value < 1 × 10
Indexed as
Nucleic Acid ConformationPolymorphism, Single NucleotideFemaleGenome-Wide Association StudyHumansLung NeoplasmsMaleRisk FactorsRNA, Long NoncodingRNA, Long Noncoding
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