ArticleScientific reports2016
In-vivo Dynamics of the Human Hippocampus across the Menstrual Cycle.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.
- Sex and gender differences in memory in epilepsy: a systematic review and meta-analysis.Biology of sex differences · 2025Pooled it
- Adolescent Hormonal Contraceptive Use in the Context of Brain Development and Depression Risk: A Review and Considerations for Future Research.Biological psychiatry global open science · 2026Review
- Hippocampus-Ventral Striatum Connectivity Is Associated With Binge Drinking Frequency in Adults.Hippocampus · 2026Article
- Single-cell map of the female brain across reproductive transitions.bioRxiv : the preprint server for biology · 2026Article
- Progesterone-associated adjustments in brain structure during menstruation and the periovulatory phase-an MRI study.EBioMedicine · 2026Article
- Menstrual cycle modulates the effect of BDNF Val66Met variant on category learning.Biology of sex differences · 2026Article
- Neurobiological Signatures of Endometriosis: Characterizing Pain, Cognition, and Brain Morphology.bioRxiv : the preprint server for biology · 2026Article
- A standardized non-linear approach to studying menstrual cycle effects on brain and behavior.Frontiers in cognition · 2026Article
- Hippocampal tissue mechanics are sensitive to fluctuations in oestrogen across the rat oestrous cycle.Brain communications · 2026Article
- Lasting effects of oral contraceptives on fear responses to a safe context.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- CSF estrogens' relationships to neuroinflammatory markers and brain networks in middle-aged and older black and white women.Journal of neuroinflammation · 2025Article
- Egr1 is a sex-dependent regulator of neuronal chromatin, structural plasticity, and behaviour.Nature communications · 2025Article
- Inter- and intra-individual differences in brain sex map to neuroendocrine profiles.bioRxiv : the preprint server for biology · 2025Article
- Trait- versus state- grey matter volume alterations in premenstrual dysphoric disorder.BMC psychiatry · 2025Article
- Hormonal milieu influences whole-brain structural dynamics across the menstrual cycle using dense sampling in multiple individuals.Nature neuroscience · 2025Article
- White Matter Regional Volumes in Relation to Menstrual Cycle Phase and Premenstrual Dysphoric Disorder.Biological psychiatry global open science · 2025Article
- Sex differences of synaptic plasticity and microglial remodeling in the dorsal hippocampus following trigeminal nerve injury in mice.Neurobiology of disease · 2025Article
- Sex differences in the impact of genetic and clinical risk factors for Alzheimer's disease in midlife.Journal of Alzheimer's disease : JAD · 2025Article
- White matter microstructural changes across the menstrual cycle: a differential tractography study.Neuroradiology · 2025Article
- Menstrual cycle and perceived stress predict performance on the mnemonic similarity task.PloS one · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impact of subtle sex-hormonal fluctuations on human hippocampal structure in health is unclear. We tested the feasibility of longitudinal neuroimaging in conjunction with rigorous menstrual cycle monitoring to evaluate potential changes in hippocampal microstructure associated with physiological sex-hormonal changes. Thirty longitudinal diffusion weighted imaging scans of a single healthy female subject were acquired across two full menstrual cycles. We calculated hippocampal fractional anisotropy (FA), a measure sensitive to changes in microstructural integrity, and investigated potential correlations with estrogen. We observed a significant positive correlation between FA values and estrogen in the hippocampus bilaterally, revealing a peak in FA closely paralleling ovulation. This exploratory, single-subject study demonstrates the feasibility of a longitudinal DWI scanning protocol across the menstrual cycle and is the first to link subtle endogenous hormonal fluctuations to changes in FA in vivo. In light of recent attempts to neurally phenotype single humans, our findings highlight menstrual cycle monitoring in parallel with highly sampled individual neuroimaging data to address fundamental questions about the dynamics of plasticity in the adult brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.