ArticleNature communications2016
Evolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 72 citations in OpenAlex.
- Cytochrome P450 enzymes in the phenylpropanoid pathway: CYP73 and CYP98 candidate genes in Chara braunii, Anthoceros agrestis, Marchantia polymorpha and Physcomitrium patens.The Plant journal : for cell and molecular biology · 2026Article
- Discovery and engineering of bacterial P450s for C-14 hydroxylation in ent-kaurane diterpenoids.Nature communications · 2026Article
- Phenolic Compounds Enhance Aluminum Tolerance in Chinese Fir (Plants (Basel, Switzerland) · 2025Article
- Study on the dynamics of fruits color related genes and metabolites during the fruit development of Zanthoxylum bungeanum 'Hanyuan'.BMC plant biology · 2025Article
- CYP98A monooxygenases: a key enzyme family in plant phenolic compound biosynthesis.Horticulture research · 2025Article
- Plant terrestrialization: an environmental pull on the evolution of multi-sourced streptophyte phenolics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Understanding metabolic diversification in plants: branchpoints in the evolution of specialized metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Cytochromes P450 evolution in the plant terrestrialization context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Current and future perspectives for enhancing our understanding of the evolution of plant metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- An ancient role for CYP73 monooxygenases in phenylpropanoid biosynthesis and embryophyte development.The EMBO journal · 2024Article
- Phenanthrene-Induced Cytochrome P450 Genes and Phenanthrene Tolerance Associated withPlants (Basel, Switzerland) · 2024Article
- Article
- Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model.Research (Washington, D.C.) · 2024Article
- Responses of flavonoids to solar UV radiation and gradual soil drying in two Medicago truncatula accessions.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Promiscuity, a Driver of Plant Cytochrome P450 Evolution?Biomolecules · 2023Review
- Genome-wide analysis of cytochrome P450 genes inHorticulture research · 2023Article
- Plant biosynthetic gene clusters in the context of metabolic evolution.Natural product reports · 2022Review
- Unlocking plant metabolic diversity: A (pan)-genomic view.Plant communications · 2022Review
- Article
- Function of the HYDROXYCINNAMOYL-CoA:SHIKIMATE HYDROXYCINNAMOYL TRANSFERASE is evolutionarily conserved in embryophytes.The Plant cell · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expansion of the cytochrome P450 gene family is often proposed to have a critical role in the evolution of metabolic complexity, in particular in microorganisms, insects and plants. However, the molecular mechanisms underlying the evolution of this complexity are poorly understood. Here we describe the evolutionary history of a plant P450 retrogene, which emerged and underwent fixation in the common ancestor of Brassicales, before undergoing tandem duplication in the ancestor of Brassicaceae. Duplication leads first to gain of dual functions in one of the copies. Both sister genes are retained through subsequent speciation but eventually return to a single copy in two of three diverging lineages. In the lineage in which both copies are maintained, the ancestral functions are split between paralogs and a novel function arises in the copy under relaxed selection. Our work illustrates how retrotransposition and gene duplication can favour the emergence of novel metabolic functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.