ArticleNature communications2016
An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5'Hoxd-Gli3 antagonism.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- A pivotal Wnt antagonist role promoting digit joint specification by constraining Wnt activity.Nature communications · 2026Article
- BMP-Dependent Modulation of ROS Generation and Scavenging Controls Interdigital Cell Death.Development, growth & differentiation · 2026Article
- Article
- Changes in Evolutionary Developmental Control Points in the Amniote Limb May Explain Hyperphalangy.Molecular biology and evolution · 2025Article
- Self-organized BMP signaling dynamics underlie the development and evolution of digit segmentation patterns in birds and mammals.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.Developmental biology · 2023Article
- The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.bioRxiv : the preprint server for biology · 2023Article
- Air-breathing behavior underlies the cell death in limbs of Rana pirica tadpoles.Zoological letters · 2023Article
- Digits in a dish: AnFrontiers in cell and developmental biology · 2023Article
- Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice.Developmental cell · 2022Article
- Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- BMP signaling and skeletal development in fibrodysplasia ossificans progressiva (FOP).Developmental dynamics : an official publication of the American Association of Anatomists · 2022Review
- Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates.Current biology : CB · 2021Article
- Selection on Phalanx Development in the Evolution of the Bird Wing.Molecular biology and evolution · 2021Article
- Dbx2 regulation in limbs suggests interTAD sharing of enhancers.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Dysregulated BMP signaling through ACVR1 impairs digit joint development in fibrodysplasia ossificans progressiva (FOP).Developmental biology · 2021Article
- Regulation of the limb shape during the development of the Chinese softshell turtles.Evolution & development · 2020Article
- A dot-stripe Turing model of joint patterning in the tetrapod limb.Development (Cambridge, England) · 2020Article
- The formation of the thumb requires direct modulation ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Developmental Phenotype of the Great Toe in Fibrodysplasia Ossificans Progressiva.Frontiers in cell and developmental biology · 2020Article
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9 authors.
Funding
Abstract
The number of phalanges and joints are key features of digit 'identity' and are central to limb functionality and evolutionary adaptation. Prior chick work indicated that digit phalanges and their associated joints arise in a different manner than the more sparsely jointed long bones, and their identity is regulated by differential signalling from adjacent interdigits. Currently, there is no genetic evidence for this model, and the molecular mechanisms governing digit joint specification remain poorly understood. Using genetic approaches in mouse, here we show that functional 5'Hoxd-Gli3 antagonism acts indirectly, through Bmp signalling from the interdigital mesenchyme, to regulate specification of joint progenitors, which arise in conjunction with phalangeal precursors at the digit tip. Phalanx number, although co-regulated, can be uncoupled from joint specification. We propose that 5'Hoxd genes and Gli3 are part of an interdigital signalling centre that sets net Bmp signalling levels from different interdigits to coordinately regulate phalanx and joint formation.
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