ReviewPharmaceuticals (Basel, Switzerland)2010
Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections.
Review in Pharmaceuticals (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- The Coexistence ofInternational journal of molecular sciences · 2024Article
- Sensor system for analysis of biofilm sensitivity to ampicillin.Applied microbiology and biotechnology · 2024Article
- Anti-infective potential of plant-derived quorum sensing inhibitors against multi-drug resistant human and aquatic bacterial pathogens.World journal of microbiology & biotechnology · 2023Article
- Oligopeptide Sortase Inhibitor ModulatesAntibiotics (Basel, Switzerland) · 2022Article
- A Combination of the Natural Molecules Gallic Acid and Carvacrol EradicatesInternational journal of molecular sciences · 2022Article
- Multidrug-Resistant Biofilm, Quorum Sensing, Quorum Quenching, and Antibacterial Activities of Indole Derivatives as Potential Eradication Approaches.BioMed research international · 2022Review
- Cadaverine Is a Switch in the Lysine Degradation Pathway inFrontiers in cellular and infection microbiology · 2022Article
- Dual Antibiotic and Diffusible Signal Factor Combination Nanoliposomes for CombatingAdvanced pharmaceutical bulletin · 2021Article
- Unsaturated Fatty Acids Control Biofilm Formation ofAntibiotics (Basel, Switzerland) · 2020Article
- The Role of Bacterial Biofilm in Antibiotic Resistance and Food Contamination.International journal of microbiology · 2020Review
- Unraveling the Molecular Mechanism of Selective Antimicrobial Activity of 2(5International journal of molecular sciences · 2019Article
- α-Chymotrypsin Immobilized on a Low-Density Polyethylene Surface Successfully WeakensInternational journal of molecular sciences · 2018Article
- Relationship of cell surface hydrophobicity with biofilm formation and growth rate: A study onIranian journal of basic medical sciences · 2018Article
- Bioactive Compounds Produced by Hypoxylon fragiforme against Staphylococcus aureus Biofilms.Microorganisms · 2017Article
- Control of Biofilm Formation: Antibiotics and Beyond.Applied and environmental microbiology · 2017Review
- Aurantiogliocladin inhibits biofilm formation at subtoxic concentrations.AIMS microbiology · 2017Article
- Quorum quenching: Signal jamming in dental plaque biofilms.Journal of dental sciences · 2016Review
- Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection.World journal of orthopedics · 2016Article
- Plasma surface modification as a new approach to protect urinary catheter againstIranian journal of microbiology · 2016Article
- CORR Insights(®): D-amino acid inhibits biofilm but not new bone formation in an ovine model.Clinical orthopaedics and related research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many bacteria grow on surfaces forming biofilms. In this structure, they are well protected and often high dosages of antibiotics cannot clear infectious biofilms. The formation and stabilization of biofilms are mediated by diffusible autoinducers (e.g. N-acyl homoserine lactones, small peptides, furanosyl borate diester). Metabolites interfering with this process have been identified in plants, animals and microbes, and synthetic analogues are known. Additionally, this seems to be not the only way to control biofilms. Enzymes capable of cleaving essential components of the biofilm matrix, e.g. polysaccharides or extracellular DNA, and thus weakening the biofilm architecture have been identified. Bacteria also have mechanisms to dissolve their biofilms and return to planktonic lifestyle. Only a few compounds responsible for the signalling of these processes are known, but they may open a completely novel line of biofilm control. All these approaches lead to the destruction of the biofilm but not the killing of the pathogens. Therefore, a combination of biofilm-destroying compounds and antibiotics to handle biofilm infections is proposed. In this article, different approaches to combine biofilm-controlling compounds and antibiotics to fight biofilm infections are discussed, as well as the balance between biofilm formation and virulence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.