Evidence map›Paper›PMID 27712965›Full record

ArticleNutrition (Burbank, Los Angeles County, Calif.)2017

Systemic inflammation, growth factors, and linear growth in the setting of infection and malnutrition.

Mark D DeBoer, Rebecca J Scharf, Alvaro M Leite, Alessandra Férrer, Alexandre Havt, Relana Pinkerton, Aldo A Lima, Richard L Guerrant

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition (Burbank, Los Angeles County, Calif.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 3 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 3 syntheses or guidelines pooled it, 155 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mark D DeBoerPediatric Endocrinology, Department of Pediatrics, University of Virginia, Charlottesville, VA. Electronic address: deboer@virginia.edu.
Rebecca J ScharfDevelopmental Pediatrics, Department of Pediatrics, University of Virginia, Charlottesville, VA.
Alvaro M LeiteInstitute of Biomedicine, Federal University of Ceará, Fortaleza, Brazil.
Alessandra FérrerInstitute of Biomedicine, Federal University of Ceará, Fortaleza, Brazil.
Alexandre HavtInstitute of Biomedicine, Federal University of Ceará, Fortaleza, Brazil.
Relana PinkertonCenter for Global Health, University of Virginia, Charlottesville, VA.
Aldo A LimaInstitute of Biomedicine, Federal University of Ceará, Fortaleza, Brazil.
Richard L GuerrantCenter for Global Health, University of Virginia, Charlottesville, VA.
Universidade Federal do Ceará · BRCenter for Global Health · USUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDeficits in weight gain and linear growth are seen frequently among children in areas where malnutrition and recurrent infections are common. Although both inflammation and malnutrition can result in growth hormone (GH) resistance, the interrelationships of infection, inflammation, and growth deficits in developing areas remain unclear. The aim of this study was to evaluate relationships between low levels of systemic inflammation, growth factors, and anthropometry in a case-control cohort of underweight and normal weight children in northern Brazil.

methodsWe evaluated data from 147 children ages 6 to 24 mo evaluated in the MAL-ED (Interactions of Malnutrition and Enteric Disease) case-control study following recruitment from a nutrition clinic for impoverished families in Fortaleza, Brazil. We used nonparametric tests and linear regression to evaluate relationships between current symptoms of infections (assessed by questionnaire), systemic inflammation (assessed by high-sensitivity C-reactive protein [hsCRP]), the GH insulin-like growth factor-1 (IGF-1) axis, and measures of anthropometry. All models were adjusted for age and sex.

resultsChildren with recent symptoms of diarrhea, cough, and fever (compared with those without symptoms) had higher hsCRP levels; those with recent diarrhea and fever also had lower IGF-1 and higher GH levels. Stool myeloperoxidase was positively associated with serum hsCRP. hsCRP was in turn positively associated with GH and negatively associated with IGF-1 and IGF-binding protein-3 (IGFBP-3), suggesting a state of GH resistance. After adjustment for hsCRP, IGF-1 and IGFBP-3 were positively and GH was negatively associated with Z scores for height and weight.

conclusionsInfection and inflammation were linked to evidence of GH resistance, whereas levels of GH, IGF-1, and IGFBP-3 were associated with growth indices independent of hsCRP. These data implicate complex interrelationships between infection, nutritional status, GH axis, and linear growth in children from a developing area.

Indexed as

Infant Nutritional Physiological PhenomenaNutritional StatusBiomarkersBody HeightBrazilCase-Control StudiesCohort StudiesC-Reactive ProteinCross-Sectional StudiesFemaleGrowth DisordersHumansInfantInfectionsInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IIBiomarkersC-Reactive ProteinIGF2 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IIDiarrheaGrowthIGF-1NutritionStunting

Identifiers

PMID27712965
PMCPMC5193489
OpenAlexW2475488208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.