ArticleThe European journal of neuroscience2017
Coupling between spontaneous pupillary fluctuations and brain activity relates to inattentiveness.
Article in The European journal of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- The Contribution of the Locus Ceruleus-Norepinephrine System to the Coupling between Pupil-Linked Arousal and Cortical State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Brain-Pupil Coupling Revealed Through Deep Learning of Intracranial Recordings.Human brain mapping · 2025Article
- Brainwide blood volume reflects opposing neural populations.bioRxiv : the preprint server for biology · 2025Article
- Neurovascular coupling: a review of spontaneous neocortical dynamics linking neuronal activity to hemodynamics and what we have learned from the rodent brain.Journal of neurophysiology · 2025Review
- Why is everyone talking about brain state?Trends in neurosciences · 2023Review
- Pupil size reflects activation of subcortical ascending arousal system nuclei during rest.eLife · 2023Article
- Isometric handgrip exercise speeds working memory responses in younger and older adults.Psychology and aging · 2023Article
- Arousal impacts distributed hubs modulating the integration of brain functional connectivity.NeuroImage · 2022Article
- Oscillatory entrainment to our early social or physical environment and the emergence of volitional control.Developmental cognitive neuroscience · 2022Review
- Publication guidelines and recommendations for pupillary measurement in psychophysiological studies.Psychophysiology · 2022Article
- Pupillary Dynamics Link Spontaneous and Task-Evoked Activations Recorded Directly from Human Insula.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Vigilance Effects in Resting-State fMRI.Frontiers in neuroscience · 2020Review
- Sympathetic and Parasympathetic Modulation of Pupillary Unrest.Frontiers in neuroscience · 2020Article
- Attention to Peer Feedback Through the Eyes of Adolescents with a History of Anxiety and Healthy Adolescents.Child psychiatry and human development · 2019Article
- Individual differences in baseline oculometrics: Examining variation in baseline pupil diameter, spontaneous eye blink rate, and fixation stability.Cognitive, affective & behavioral neuroscience · 2019Article
- Coupling and dynamics of cortical and autonomic signals are linked to central inhibition during the wake-sleep transition.Scientific reports · 2017Article
- A locus coeruleus-norepinephrine account of individual differences in working memory capacity and attention control.Psychonomic bulletin & review · 2017Review
- Seeing a Talker's Mouth Reduces the Effort of Perceiving Speech and Repairing Perceptual Mistakes for Listeners With Cochlear Implants.Ear and hearingArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Autonomic activity in neurological and psychiatric disorders is often dysregulated, particularly in the context of attentional behaviors. This suggests that interplay between the autonomic nervous system and aspects of the central nervous system subserving attention may be disrupted in these conditions. Better understanding these interactions and their relationship with individual variation in attentional behaviors could facilitate development of mechanistic biomarkers. We identified brain regions defined by trait-sensitive central-autonomic coupling as a first step in this process. As spontaneous neural activity measured during the resting state is sensitive to phenotypic variability, unconfounded by task performance, we examined whether spontaneous fluctuations in brain activity and an autonomic measure, pupil diameter, were coupled during the resting state, and whether that coupling predicted individual differences in attentional behavior. By employing concurrent pupillometry and fMRI during the resting state, we observed positive coupling in regions comprising cingulo-opercular, default mode, and fronto-parietal networks, as well as negative coupling with visual and sensorimotor regions. Individuals less prone to distractibility in everyday behavior demonstrated stronger positive coupling in cingulo-opercular regions often associated with sympathetic activity. Overall, our results suggest that individuals less prone to distractibility have tighter intrinsic coordination between specific brain areas and autonomic systems, which may enable adaptive autonomic shifts in response to salient environmental cues. These results suggest that incorporating autonomic indices in resting-state studies should be useful in the search for biomarkers for neurological and psychiatric disorders.
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Registered trials
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