Evidence map›Paper›PMID 27712014›Full record

ArticleGenesis (New York, N.Y. : 2000)2016

Generation of a NK1R-CreER knockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling.

Huizhen Huang, Marissa S Kuzirian, Xiaoyun Cai, Lindsey M Snyder, Jonathan Cohen, Daniel H Kaplan, Sarah E Ross

Open access · greenAbstract read
In one paragraph

Article in Genesis (New York, N.Y. : 2000), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Type-I nNOS neurons orchestrate cortical neural activity and vasomotion.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Organization of Cortical and Thalamic Input to Inhibitory Neurons in Mouse Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  8. Article
  9. The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  10. Physiology and Pathophysiology of Itch.Physiological reviews · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Huizhen HuangDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Marissa S KuzirianDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Xiaoyun CaiDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lindsey M SnyderDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jonathan CohenDepartments of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Daniel H KaplanDepartments of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sarah E RossDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · US

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
TRAINING PROGRAM FOR MD/PHD STUDENTST32GM008208 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEINMAN, RICHARD A · 1987 to 2021
$15.4M
Investigating the Neural Circuits of ItchR01AR063772 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI H Richard Koerber, Sarah Elizabeth Ross · 2013 to 2026
$6.9M
Molecular genetic dissection of the spinal microcircuits of wind-upR01NS096705 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOERBER, H RICHARD, ROSS, SARAH ELIZABETH · 2016 to 2025
$5.1M
Regulated Activation of Latent-TGFb Determines Leukocyte Occupancy of the Epidermal NicheR01AR060744 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAPLAN, DANIEL H · 2011 to 2020
$4.0M
Training in Mechanisms and Clinical Presentation of PainT32NS073548 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jami Lynn Saloman, BRADLEY K. TAYLOR · 2012 to 2026
$3.1M
Skin Dendritic Cells and Humoral ImmunityR01AR067187 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAPLAN, DANIEL H · 2015 to 2019
$1.6M
Using dual intersectional genetics to understand and modulate itchR21AR064445 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSS, SARAH ELIZABETH · 2013 to 2014
$358k
Understanding a specific microcircuit that integrates somatosensory information in the dorsal spinal cordF31NS092146 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SNYDER, LINDSEY M · 2015 to 2016
$83k
NIAMS NIH HHS R01 AR060744NIAMS NIH HHS R01 AR063772NIAMS NIH HHS R01 AR067187NIAMS NIH HHS R21 AR064445NICHD NIH HHS P30 HD018655NIGMS NIH HHS T32 GM008208NINDS NIH HHS F31 NS092146NINDS NIH HHS R01 NS096705NINDS NIH HHS T32 NS073548
6 · The paper itself

Abstract

The Neurokinin 1 Receptor (NK1R), which binds Substance P, is expressed in discrete populations of neurons throughout the nervous system, where it has numerous roles including the modulation of pain and affective behaviors. Here, we report the generation of a NK1R-CreER knockin allele, in which CreER

Indexed as

AnimalsGene Expression RegulationGene Knock-In TechniquesIntegrasesMiceNeuronsPainReceptors, Neurokinin-1Signal TransductionSpinal CordSubstance PCre recombinaseIntegrasesReceptors, Neurokinin-1Substance PCreERCre-loxP systemgeneticsNeurokinin 1 ReceptorNK1RSubstance Psubstance P receptorTACR1tamoxifen

Identifiers

PMID27712014
PMCPMC5241089
OpenAlexW2529059282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.