ArticleEnvironmental microbiology2017
Broad phylogeny and functionality of cellulosomal components in the bovine rumen microbiome.
Article in Environmental microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- The mediating role of the TyG index in the relationship between circadian syndrome and cancer among middle-aged and elderly Chinese.BMC cancer · 2025Article
- A cellulosomal double-dockerin module from Clostridium thermocellum shows distinct structural and cohesin-binding features.Protein science : a publication of the Protein Society · 2024Article
- Co-fermented defatted rice bran alters gut microbiota and improves growth performance, antioxidant capacity, immune status and intestinal permeability of finishing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Functional differentiation related to decomposing complex carbohydrates of intestinal microbes between two wild zokor species based on 16SrRNA sequences.BMC veterinary research · 2021Article
- Cellulosomes: Highly Efficient Cellulolytic Complexes.Sub-cellular biochemistry · 2021Review
- Multi-omic Directed Discovery of Cellulosomes, Polysaccharide Utilization Loci, and Lignocellulases from an Enriched Rumen Anaerobic Consortium.Applied and environmental microbiology · 2020Article
- Calcium salts of long-chain fatty acids from linseed oil decrease methane production by altering the rumen microbiome in vitro.PloS one · 2020Article
- The Cellulosome Paradigm in An Extreme Alkaline Environment.Microorganisms · 2019Article
- Islands in the stream: from individual to communal fiber degradation in the rumen ecosystem.FEMS microbiology reviews · 2019Review
- Cell Wall Hydrolases in Bacteria: Insight on the Diversity of Cell Wall Amidases, Glycosidases and Peptidases Toward Peptidoglycan.Frontiers in microbiology · 2019Review
- CELLULASE6 and MANNANASE7 Affect Cell Differentiation and Silique Dehiscence.Plant physiology · 2018Article
- Combination ofFrontiers in microbiology · 2018Article
- A metagenomic analysis of the camel rumen's microbiome identifies the major microbes responsible for lignocellulose degradation and fermentation.Biotechnology for biofuels · 2018Article
- Ninety-nine de novo assembled genomes from the moose (Alces alces) rumen microbiome provide new insights into microbial plant biomass degradation.The ISME journal · 2017Article
- Unique organization and unprecedented diversity of theBiotechnology for biofuels · 2017Article
- Comparative Metagenomics of Cellulose- and Poplar Hydrolysate-Degrading Microcosms from Gut Microflora of the Canadian Beaver (Frontiers in microbiology · 2017Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The cellulosome is an extracellular multi-enzyme complex that is considered one of the most efficient plant cell wall-degrading strategies devised by nature. Its unique modular architecture, achieved by high affinity and specific interaction between protein modules (cohesins and dockerins) enables formation of various enzyme combinations. Extensive research has been dedicated to the mechanistic nature of the cellulosome complex. Nevertheless, little is known regarding its distribution and abundance among microbes in natural plant fibre-rich environments. Here, we explored these questions in bovine rumen microbial communities, specialized in efficient degradation of lignocellulosic plant material. We bioinformatically screened for cellulosomal modules in this complex environment using a previously published ultra-deep fibre-adherent rumen metagenome. Intriguingly, a large portion of the functions of the dockerin-containing proteins were related to alternative biological processes, and not necessarily to the classic fibre degradation function. Our analysis was experimentally validated by characterizing specific interactions between selected cohesins and dockerins and revealed that cellulosome is a more generalized strategy used by diverse bacteria, some of which were not previously associated with cellulosome production. Remarkably, our results provide additional proof of similarity among rumen microbial communities worldwide. This study suggests a broader and widespread role for the cellulosomal machinery in nature.
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