Evidence map›Paper›PMID 27711999›Full record

ReviewChemistry (Weinheim an der Bergstrasse, Germany)2017

NMR Hyperpolarization Techniques of Gases.

Danila A Barskiy, Aaron M Coffey, Panayiotis Nikolaou, Dmitry M Mikhaylov, Boyd M Goodson, Rosa T Branca, George J Lu, Mikhail G Shapiro, Ville-Veikko Telkki, Vladimir V Zhivonitko and 10 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 164 citations in OpenAlex.

  1. Article
  2. Quantitative Nuclear Magnetic Resonance Spectroscopy with Overhauser Dynamic Nuclear Polarization.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025
    Article
  3. Parahydrogen-Hyperpolarized Propane-The journal of physical chemistry. A · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Live magnetic observation of parahydrogen hyperpolarization dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Molecules, Up Your Spins!Molecules (Basel, Switzerland) · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 12 institutions in 6 countries.

Danila A BarskiyDepartment of Radiology, Department of Biomedical Engineering, Department of Physics, Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN, 37232, USA.ORCID http://orcid.org/0000-0002-2819-7584
Aaron M CoffeyDepartment of Radiology, Department of Biomedical Engineering, Department of Physics, Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN, 37232, USA.
Panayiotis NikolaouDepartment of Radiology, Department of Biomedical Engineering, Department of Physics, Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN, 37232, USA.
Dmitry M MikhaylovHuazhong University of Science and Technology, Wuhan, 100044, China.ORCID http://orcid.org/0000-0002-8333-6487
Boyd M GoodsonSouthern Illinois University, Department of Chemistry and Biochemistry, Materials Technology Center, Carbondale, IL, 62901, USA.ORCID http://orcid.org/0000-0001-6079-5077
Rosa T BrancaDepartment of Physics and Astronomy, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0002-6871-1824
George J LuDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Mikhail G ShapiroDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.ORCID http://orcid.org/0000-0002-0291-4215
Ville-Veikko TelkkiNMR Research Unit, University of Oulu, 90014, Oulu, Finland.ORCID http://orcid.org/0000-0003-0846-6852
Vladimir V ZhivonitkoInternational Tomography Center SB RAS, 630090, Novosibirsk, Russia.
Igor V KoptyugInternational Tomography Center SB RAS, 630090, Novosibirsk, Russia.ORCID http://orcid.org/0000-0003-3480-7649
Oleg G SalnikovInternational Tomography Center SB RAS, 630090, Novosibirsk, Russia.
Kirill V KovtunovInternational Tomography Center SB RAS, 630090, Novosibirsk, Russia.ORCID http://orcid.org/0000-0001-7577-9619
Valerii I BukhtiyarovBoreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090, Novosibirsk, Russia.ORCID http://orcid.org/0000-0003-4382-1207
Matthew S RosenMGH/A.A. Martinos Center for Biomedical Imaging, Boston, MA, 02129, USA.
Michael J BarlowRespiratory Medicine Department, Queen's Medical Centre, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.ORCID http://orcid.org/0000-0003-3609-6043
Shahideh SafaviRespiratory Medicine Department, Queen's Medical Centre, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
Ian P HallRespiratory Medicine Department, Queen's Medical Centre, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.ORCID http://orcid.org/0000-0001-9933-3216
Leif SchröderMolecular Imaging, Department of Structural Biology, Leibniz-Institut für Molekulare Pharmakologie (FMP), 13125, Berlin, Germany.ORCID http://orcid.org/0000-0003-4901-0325
Eduard Y ChekmenevDepartment of Radiology, Department of Biomedical Engineering, Department of Physics, Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN, 37232, USA.ORCID http://orcid.org/0000-0002-8745-8801
Novosibirsk State University · RUUniversity of Nottingham · GBVanderbilt University · USCalifornia Institute of Technology · USAthinoula A. Martinos Center for Biomedical Imaging · USBoreskov Institute of Catalysis · RUHuazhong University of Science and Technology · CNLeibniz-Forschungsinstitut für Molekulare Pharmakologie · DEOulu University of Applied Sciences · FIRussian Academy of Sciences · RUSouthern Illinois University Carbondale · USUniversity of North Carolina at Chapel Hill · US

Funding

Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imagingR21EB020323 · NIBIB · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI CHEKMENEV, EDUARD, GOODSON, BOYD M · 2015 to 2016
$416k
Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imagingR21EB018014 · NIBIB · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI CHEKMENEV, EDUARD, GOODSON, BOYD M · 2014 to 2015
$407k
Ultra-fast molecular MRI of human adipose tissue with hyperpolarized xenon-129 contrast agentF32EB021840 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, AARON MICHAEL · 2015 to 2017
$109k
NIBIB NIH HHS F32 EB021840NIBIB NIH HHS R21 EB018014NIBIB NIH HHS R21 EB020323NIBIB NIH HHS T32 EB001628Wellcome Trust
6 · The paper itself

Abstract

Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4-8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can often be readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This Minireview covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

Indexed as

gashyperpolarizationMRINMRpropaneXe-129

Identifiers

PMID27711999
PMCPMC5462469
OpenAlexW2528607052

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.