ArticleDalton transactions (Cambridge, England : 2003)2016
How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study.
Article in Dalton transactions (Cambridge, England : 2003), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Cu(I) Is a Game Changer in the Arrest of Cu(Aβ)-Induced ROS Production in the Presence of Competing Zn(II) Ions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Evaluation of a New Methylimidazole-Containing Thiosemicarbazone as a CuChemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Modeling Chelator Substituent Effects as Therapeutic Targets in Neurodegenerative Diseases.ACS omega · 2025Article
- Sequence-Activity Relationship of ATCUN Peptides in the Context of Alzheimer's Disease.Molecules (Basel, Switzerland) · 2022Article
- Why the Ala-His-His Peptide Is an Appropriate Scaffold to Remove and Redox Silence Copper Ions from the Alzheimer's-Related Aβ Peptide.Biomolecules · 2022Article
- Copper Toxicity Links to Pathogenesis of Alzheimer's Disease and Therapeutics Approaches.International journal of molecular sciences · 2020Review
- The Glutathione/Metallothionein System Challenges the Design of Efficient OAngewandte Chemie (International ed. in English) · 2020Article
- Zinc Chloride Exposure Inhibits Brain Acetylcholine Levels, Produces Neurotoxic Signatures, and Diminishes Memory and Motor Activities in Adult Zebrafish.International journal of molecular sciences · 2018Article
- NChemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- A Metallo Pro-Drug to Target CuChemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Oxidative stress and the amyloid beta peptide in Alzheimer's disease.Redox biology · 2018Review
- A Trishistidine Pseudopeptide with Ability to Remove Both CuChemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Mutual interference of Cu and Zn ions in Alzheimer's disease: perspectives at the molecular level.Dalton transactions (Cambridge, England : 2003) · 2017Review
- Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease.Chemical science · 2017Article
- Role of Copper in the Onset of Alzheimer's Disease Compared to Other Metals.Frontiers in aging neuroscience · 2017Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The role of Cu and Zn ions in Alzheimer's disease is linked to the consequences of their coordination to the amyloid-β (Aβ) peptide, i.e. to the modulation of Aβ aggregation and to the production of Reactive Oxygen Species (ROS), two central events of the so-called amyloid cascade. The role of both ions in Aβ aggregation is still controversial. Conversely the higher toxicity of the redox competent Cu ions (compared to the redox inert Zn ions) in ROS production is acknowledged. Thus the Cu ions can be considered as the main therapeutic target. Because Zn ions are present in higher quantity than Cu ions in the synaptic cleft, they can prevent detoxification of Cu by chelators unless they have an unusually high Cu over Zn selectivity. We describe a proof-of-concept study where the role of Zn on the metal swap reaction between two prototypical ligands and the Cu(Aβ) species has been investigated by several complementary spectroscopic techniques (UV-Vis, EPR and XANES). The first ligand has a higher Cu over Zn selectivity relative to the one of Aβ peptide while the second one exhibits a classical Cu over Zn selectivity. How Zn impacts the effect of the ligands on Cu-induced ROS production and Aβ aggregation is also reported.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.