Evidence map›Paper›PMID 27711445›Full record

ArticlePhysical chemistry chemical physics : PCCP2016

Structures of the kinetically trapped i-motif DNA intermediates.

Alyssa Garabedian, David Butcher, Jennifer L Lippens, Jaroslava Miksovska, Prem P Chapagain, Daniele Fabris, Mark E Ridgeway, Melvin A Park, Francisco Fernandez-Lima

Abstract read
In one paragraph

Article in Physical chemistry chemical physics : PCCP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Collision-Induced Unfolding of High-Journal of the American Society for Mass Spectrometry · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Structural Heterogeneity of Human Histone H2A.1.The journal of physical chemistry. B · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Evidence of Cis/Trans-Isomerization at Pro7/Pro16 in the Lasso Peptide Microcin J25.Journal of the American Society for Mass Spectrometry · 2019
    Article
  13. Article
  14. Article
  15. Article
  16. Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS.Journal of the American Society for Mass Spectrometry · 2018
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alyssa GarabedianDepartment of Chemistry and Biochemistry, Florida International University, Miami, USA. fernandf@fiu.edu.
David ButcherDepartment of Chemistry and Biochemistry, Florida International University, Miami, USA. fernandf@fiu.edu.
Jennifer L LippensThe RNA Institute, University at Albany, Albany, USA.
Jaroslava MiksovskaDepartment of Chemistry and Biochemistry, Florida International University, Miami, USA. fernandf@fiu.edu and Biomolecular Science Institute, Florida International University, Miami, USA.
Prem P ChapagainBiomolecular Science Institute, Florida International University, Miami, USA and Department of Physics, Florida International University, Miami, USA.
Daniele FabrisThe RNA Institute, University at Albany, Albany, USA.
Mark E RidgewayBruker Daltonics Inc., Billerica, Massachusetts, USA.
Melvin A ParkBruker Daltonics Inc., Billerica, Massachusetts, USA.
Francisco Fernandez-LimaDepartment of Chemistry and Biochemistry, Florida International University, Miami, USA. fernandf@fiu.edu and Biomolecular Science Institute, Florida International University, Miami, USA.

Funding

Mass Spectrometry based molecular imaging of native biological nanodomainsR00GM106414 · NIGMS · FLORIDA INTERNATIONAL UNIVERSITY · PI FERNANDEZ-LIMA, FRANCISCO · 2012 to 2014
$731k
NIGMS NIH HHS R00 GM106414
6 · The paper itself

Abstract

In the present work, the conformational dynamics and folding pathways of i-motif DNA were studied in solution and in the gas-phase as a function of the solution pH conditions using circular dichroism (CD), photoacoustic calorimetry analysis (PAC), trapped ion mobility spectrometry-mass spectrometry (TIMS-MS), and molecular dynamics (MD). Solution studies showed at thermodynamic equilibrium the existence of a two-state folding mechanism, whereas during the pH = 7.0 → 4.5 transition a fast and slow phase (ΔH

Indexed as

CalorimetryCircular DichroismCytosineDNAHydrogen-Ion ConcentrationIon Mobility SpectrometryKineticsMolecular Dynamics SimulationNucleic Acid ConformationNucleotide MotifsSpectrometry, Mass, Electrospray IonizationThermodynamicsCytosineDNA

Identifiers

PMID27711445
PMCPMC5652045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.