ArticlePLoS pathogens2016
Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- A host anti-amyloidogenic stomach-specific protein inhibits colonization and biofilm formation by adherent invasive Escherichia coli in the colon.Research square · 2026Article
- The interplay mechanisms between gut microbiota and ferroptosis in inflammatory bowel disease.Frontiers in immunology · 2026Review
- Evidence for a Causal Role for Escherichia coli Strains Identified as Adherent-Invasive (AIEC) in Intestinal Inflammation.mSphere · 2023Article
- Adherent-invasiveFrontiers in microbiology · 2023Article
- Fecal microbiota transplantation in the metabolic diseases: Current status and perspectives.World journal of gastroenterology · 2022Review
- Adherent-Invasive and Non-InvasiveMicroorganisms · 2021Article
- Gut microbiota and inflammatory bowel disease: The current status and perspectives.World journal of clinical cases · 2021Review
- The autoimmune susceptibility gene,Gut microbes · 2020Article
- Article
- Adherent-InvasiveInternational journal of molecular sciences · 2020Review
- Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut.Nature microbiology · 2020Article
- Pathobiont release from dysbiotic gut microbiota biofilms in intestinal inflammatory diseases: a role for iron?Journal of biomedical science · 2019Review
- Pathogenic and non-pathogenicDisease models & mechanisms · 2018Article
- A multi-phenotypic imaging screen to identify bacterial effectors by exogenous expression in a HeLa cell line.Scientific data · 2018Article
- Correction: Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period.PLoS pathogens · 2018Article
- A polymicrobial view of disease potential in Crohn's-associated adherent-invasive E. coli.Gut microbes · 2018Article
- The multifaceted virulence of adherent-invasiveGut microbesReview
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crohn's disease (CD) is a chronic inflammatory condition of diverse etiology. Exposure to foodborne pathogens causing acute gastroenteritis produces a long-term risk of CD well into the post-infectious period but the mechanistic basis for this ongoing relationship to disease onset is unknown. We developed two novel models to study the comorbidity of acute gastroenteritis caused by Salmonella Typhimurium or Citrobacter rodentium in mice colonized with adherent-invasive Escherichia coli (AIEC), a bacterial pathobiont linked to CD. Here, we show that disease activity in the post-infectious period after gastroenteritis is driven by the tissue-associated expansion of the resident AIEC pathobiont, with an attendant increase in immunopathology, barrier defects, and delays in mucosal restitution following pathogen clearance. These features required AIEC resistance to host defense peptides and a fulminant inflammatory response to the enteric pathogen. Our results suggest that individuals colonized by AIEC at the time of acute infectious gastroenteritis may be at greater risk for CD onset. Importantly, our data identify AIEC as a tractable disease modifier, a finding that could be exploited in the development of therapeutic interventions following infectious gastroenteritis in at-risk individuals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.