ArticlePloS one2016
Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Retinal OCT Parameters and Physiological Dynamics as an Effect of Anesthesia in C57BL/6J Mice.Investigative ophthalmology & visual science · 2026Article
- Blood flow analysis of retinal neovascularisations in a VLDLR mouse model using contrast-enhanced optical coherence tomography.Biomedical optics express · 2026Article
- Long-acting fenofibrate-loaded microparticles for treating retinal disorders.International journal of pharmaceutics · 2026Article
- Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimer's disease reveals differences dependent on genotype and sex.Biomedical optics express · 2026Article
- Comparative Investigation of the Retinal Phenotype of Three Mouse Models of Alzheimer's Disease With Optical Coherence Tomography.Investigative ophthalmology & visual science · 2025Article
- Sustained release of a novel non-fibrate PPARα agonist from microparticles for neuroprotection in murine models of age-related macular degeneration.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels.Angiogenesis · 2024Article
- Quantification of microvascular change of retinal degeneration in Royal College of Surgeons rats using high-resolution spectral domain optical coherence tomography angiography.Journal of biomedical optics · 2023Article
- Synthesizing the degree of polarization uniformity from non-polarization-sensitive optical coherence tomography signals using a neural network.Biomedical optics express · 2023Article
- Degeneration of Melanin-Containing Structures Observed Longitudinally in the Eyes of SOD1-/- Mice Using Intensity, Polarization, and Spectroscopic OCT.Translational vision science & technology · 2022Article
- Pulsatile tissue deformation dynamics of the murine retina and choroid mapped by 4D optical coherence tomography.Biomedical optics express · 2022Article
- Morphometric and Microstructural Changes During Murine Retinal Development Characterized Using In Vivo Optical Coherence Tomography.Investigative ophthalmology & visual science · 2021Article
- High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice.Biomedical optics express · 2021Article
- Vascular morphology and blood flow signatures for differential artery-vein analysis in optical coherence tomography of the retina.Biomedical optics express · 2021Article
- Quantitative multi-contrastBiomedical optics express · 2020Article
- Optical Coherence Tomography Findings in the Retinas of SOD1 Knockout Mice.Translational vision science & technology · 2020Article
- Retinal analysis of a mouse model of Alzheimer's disease with multicontrast optical coherence tomography.Neurophotonics · 2020Article
- En-Face Optical Coherence Tomography Angiography for Longitudinal Monitoring of Retinal Injury.Applied sciences (Basel, Switzerland) · 2019Article
- Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model.Journal of experimental neuroscience · 2019Article
- Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a multi-functional optical coherence tomography (OCT) imaging approach to study retinal changes in the very-low-density-lipoprotein-receptor (VLDLR) knockout mouse model with a threefold contrast. In the retinas of VLDLR knockout mice spontaneous retinal-chorodoidal neovascularizations form, having an appearance similar to choroidal and retinal neovascularizations (CNV and RNV) in neovascular age-related macular degeneration (AMD) or retinal angiomatous proliferation (RAP). For this longitudinal study, the mice were imaged every 4 to 6 weeks starting with an age of 4 weeks and following up to the age of 11 months. Significant retinal changes were identified by the multi-functional imaging approach offering a threefold contrast: reflectivity, polarization sensitivity (PS) and motion contrast based OCT angiography (OCTA). By use of this intrinsic contrast, the long-term development of neovascularizations was studied and associated processes, such as the migration of melanin pigments or retinal-choroidal anastomosis, were assessed in vivo. Furthermore, the in vivo imaging results were validated with histological sections at the endpoint of the experiment. Multi-functional OCT proves as a powerful tool for longitudinal retinal studies in preclinical research of ophthalmic diseases. Intrinsic contrast offered by the functional extensions of OCT might help to describe regulative processes in genetic animal models and potentially deepen the understanding of the pathogenesis of retinal diseases such as wet AMD.
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