ArticlePLoS pathogens2016
Distinct Effects of p19 RNA Silencing Suppressor on Small RNA Mediated Pathways in Plants.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 77 citations in OpenAlex.
- Integrative Roles of miRNAs and circRNAs in Plant Antiviral Gene Regulation and Autophagy.Plants (Basel, Switzerland) · 2025Review
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- In-silico prediction of coat protein structure of Indian citrus ringspot virus and their interactions with the Argonaut2/DCL4 proteins.Virusdisease · 2025Article
- Identification of an RNA silencing suppressor encoded by an Indian citrus ringspot virus.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- The plant siRNA landscape.The Plant cell · 2024Review
- Function and regulation of plant ARGONAUTE proteins in response to environmental challenges: a review.PeerJ · 2024Review
- Toward Transgene-Free Transposon-Mediated Biological Mutagenesis for Plant Breeding.International journal of molecular sciences · 2023Review
- Induction and suppression of gene silencing in plants by nonviral microbes.Molecular plant pathology · 2023Review
- Viral synergism suppresses R gene-mediated resistance by impairing downstream defense mechanisms in soybean.Plant physiology · 2023Article
- Infection Defects of RNA and DNA Viruses Induced by Antiviral RNA Interference.Microbiology and molecular biology reviews : MMBR · 2023Review
- An unnatural enzyme with endonuclease activity towards small non-coding RNAs.Nature communications · 2023Article
- Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A contemporary reassessment of the enhanced transient expression system based on the tombusviral silencing suppressor protein P19.The Plant journal : for cell and molecular biology · 2023Article
- Article
- The miRNome function transitions from regulating developmental genes to transposable elements during pollen maturation.The Plant cell · 2022Article
- Identification of Silencing Suppressor Protein Encoded by Strawberry Mottle Virus.Frontiers in plant science · 2022Article
- Viral suppressor of RNA silencing in vascular plants also interferes with the development of the bryophyte Physcomitrella patens.Plant, cell & environment · 2022Article
- Article
- Argonaute 2 Controls Antiviral Activity against Sweet Potato Mild Mottle Virus inPlants (Basel, Switzerland) · 2021Article
- RNAi activation with homologous and heterologous sequences that induce resistance against the begomovirus3 Biotech · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA silencing is one of the main defense mechanisms employed by plants to fight viruses. In change, viruses have evolved silencing suppressor proteins to neutralize antiviral silencing. Since the endogenous and antiviral functions of RNA silencing pathway rely on common components, it was suggested that viral suppressors interfere with endogenous silencing pathway contributing to viral symptom development. In this work, we aimed to understand the effects of the tombusviral p19 suppressor on endogenous and antiviral silencing during genuine virus infection. We showed that ectopically expressed p19 sequesters endogenous small RNAs (sRNAs) in the absence, but not in the presence of virus infection. Our presented data question the generalized model in which the sequestration of endogenous sRNAs by the viral suppressor contributes to the viral symptom development. We further showed that p19 preferentially binds the perfectly paired ds-viral small interfering RNAs (vsiRNAs) but does not select based on their sequence or the type of the 5' nucleotide. Finally, co-immunoprecipitation of sRNAs with AGO1 or AGO2 from virus-infected plants revealed that p19 specifically impairs vsiRNA loading into AGO1 but not AGO2. Our findings, coupled with the fact that p19-expressing wild type Cymbidium ringspot virus (CymRSV) overcomes the Nicotiana benthamiana silencing based defense killing the host, suggest that AGO1 is the main effector of antiviral silencing in this host-virus combination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.