ArticleNature medicine2016
SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity.
Open access · greenAbstract readLetterComment
In one paragraph
Article in Nature medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 92 citations in OpenAlex.
- Structural and functional relevance of the DUF4352 domain in antiviral immunity and physiology of mycobacteria.Nucleic acids research · 2025Article
- ssDNA and ssRNA Promote Phase Condensation of SAMHD1.Biochemistry · 2025Article
- SAMHD1 enhances HIV-1-induced apoptosis in monocytic cells via the mitochondrial pathway.mBio · 2025Article
- dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction.Journal of virology · 2025Review
- Mechanisms of Immune Evasion in HIV-1: The Role of Virus-Host Protein Interactions.Current issues in molecular biology · 2025Review
- Article
- Review
- Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3.Virology journal · 2024Article
- Interactions between HIV proteins and host restriction factors: implications for potential therapeutic intervention in HIV infection.Frontiers in immunology · 2024Review
- Review
- Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.Nucleic acids research · 2023Article
- Targeting SAMHD1: To overcome multiple anti-cancer drugs resistance in hematological malignancies.Genes & diseases · 2023Review
- Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner.The Journal of experimental medicine · 2023Article
- SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks.Nature communications · 2022Article
- Targeting the DNA damage response and repair in cancer through nucleotide metabolism.Molecular oncology · 2022Review
- Expression of SAMHD1 and its mutation on prognosis of colon cancer.Oncology letters · 2022Article
- Host Restrictive Factors Are the Emerging Storm Troopers Against Enterovirus: A Mini-Review.Frontiers in immunology · 2022Review
- Nucleotide Pool Imbalance and Antibody Gene Diversification.Vaccines · 2021Review
- SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells.Nature communications · 2021Article
- SAMHD1 Inhibits Multiple Enteroviruses by Interfering with the Interaction between VP1 and VP2 Proteins.Journal of virology · 2021Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Jenna M AntonucciCenter for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, USA.
Corine St GelaisCenter for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, USA.
Suresh de SilvaCenter for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, USA.
Jacob S YountDepartment of Microbial Infection and Immunity, Ohio State University, Columbus, Ohio, USA.
Chenxiang TangDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, USA.
Xiaoyun JiDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, USA.
Caitlin ShepardDepartment of Pediatrics, Center for Drug Discovery, Emory University School of Medicine, Atlanta, Georgia, USA.
Yong XiongDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, USA.
Baek KimDepartment of Pediatrics, Center for Drug Discovery, Emory University School of Medicine, Atlanta, Georgia, USA.
Li WuCenter for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-5468-2487
The Ohio State University · USYale University · USEmory University · US
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MReplication fidelity and lentiviral pathogenesisR01AI049781 · NIAID · UNIVERSITY OF ROCHESTER · PI KIM, BAEK · 2002 to 2016
$4.9MViral Hijacking of Host Membrane Trafficking PathwaysR01AI102778 · NIAID · YALE UNIVERSITY · PI GUATELLI, JOHN C., XIONG, YONG · 2013 to 2017
$3.0MSAMHD1 controls dNTP pool and HIV sensitivity to NRTIsR01GM104198 · NIGMS · UNIVERSITY OF ROCHESTER · PI KIM, BAEK · 2012 to 2018
$2.3MMechanisms of SAMHD1-mediated HIV-1 restriction in dendritic cellsR01AI104483 · NIAID · OHIO STATE UNIVERSITY · PI WU, LI · 2013 to 2016
$1.5MMechanisms Underlying Dendritic Cell-mediated HIV TransmissionR01AI068493 · NIAID · OHIO STATE UNIVERSITY · PI WU, LI · 2006 to 2010
$1.5MReplicational Fidelity and Lentivial PathogenesisR56AI049781 · NIAID · EMORY UNIVERSITY · PI KIM, BAEK · 2017 to 2017
$390kNovel role of SAMHD1 as a tumor suppressor in cutaneous T-cell lymphomasR21CA181997 · NCI · OHIO STATE UNIVERSITY · PI WU, LI · 2014 to 2015
$368kMolecular Control of IFITM3 in Restricting Influenza Virus InfectionR56AI114826 · NIAID · OHIO STATE UNIVERSITY · PI YOUNT, JACOB · 2015 to 2015
$366kMolecular basis of HIV restriction by SAMHD1K99AI120845 · NIAID · YALE UNIVERSITY · PI JI, XIAOYUN · 2015 to 2016
$209kNCI NIH HHS P30 CA016058NCI NIH HHS R21 CA181997NIAID NIH HHS K99 AI120845NIAID NIH HHS R01 AI049781NIAID NIH HHS R01 AI068493NIAID NIH HHS R01 AI102778NIAID NIH HHS R01 AI104483NIAID NIH HHS R56 AI049781NIAID NIH HHS R56 AI114826NIGMS NIH HHS R01 GM104198
Abstract
PubMed holds no abstract for this paper.
Indexed as
HIV-1Monomeric GTP-Binding ProteinsHIV InfectionsHumansRibonucleasesSAM Domain and HD Domain-Containing Protein 1Virus ReplicationMonomeric GTP-Binding ProteinsRibonucleasesSAM Domain and HD Domain-Containing Protein 1
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.